Evaluation of European coeliac disease risk variants in a north Indian population

被引：18

作者：

Senapati, Sabyasachi ^{[1
]}

Gutierrez-Achury, Javier ^{[2
]}

Sood, Ajit ^{[3
]}

Midha, Vandana ^{[4
]}

Szperl, Agata ^{[2
]}

Romanos, Jihane ^{[2
]}

Zhernakova, Alexandra ^{[2
]}

Franke, Lude ^{[2
]}

Alonso, Santos ^{[5
]}

Thelma, B. K. ^{[1
]}

Wijmenga, Cisca ^{[2
]}

Trynka, Gosia ^{[2
]}

机构：

[1] Univ Delhi, Dept Genet, New Delhi, India

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

[3] Dayanand Med Coll & Hosp, Dept Gastroenterol, Ludhiana, Punjab, India

[4] Dayanand Med Coll & Hosp, Dept Med, Ludhiana, Punjab, India

[5] Univ Basque Country, Dept Genet Phys Anthropol & Anim Physiol, Leioa, Spain

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2015年 / 23卷 / 04期

基金：

欧洲研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; TISSUE-TRANSGLUTAMINASE ANTIBODY; RHEUMATOID-ARTHRITIS RISK; SUSCEPTIBILITY LOCUS; 1ST-DEGREE RELATIVES; MULTIPLE COMMON; METAANALYSIS; PREVALENCE; GENE; MICA;

D O I：

10.1038/ejhg.2014.137

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies in European populations have contributed to a better understanding of the genetics of complex diseases, for example, in coeliac disease (CeD), studies of over 23 000 European samples have reported association to the HLA locus and another 39 loci. However, these associations have not been evaluated in detail in other ethnicities. We sought to better understand how disease-associated loci that have been mapped in Europeans translate to a disease risk for a population with a different ethnic background. We therefore performed a validation of European risk loci for CeD in 497 cases and 736 controls of north Indian origin. Using a dense-genotyping platform (Immunochip), we confirmed the strong association to the HLA region (rs2854275, P = 8.2 x 10(-49)). Three loci showed suggestive association (rs4948256, P = 9.3 x 10(-7), rs4758538, P = 8.6 x 10(-5) and rs17080877, P = 2.7 x 10(-5)). We directly replicated five previously reported European variants (Po0.05; mapping to loci harbouring FASLG/TNFSF18, SCHIP1/IL12A, PFKFB3/PRKCQ, ZMIZ1 and ICOSLG). Using a transferability test, we further confirmed association at PFKFB3/PRKCQ (rs2387397, P = 2.8 x 10(-4)) and PTPRK/THEMIS (rs55743914, P = 3.4 x 10(-4)). The north Indian population has a higher degree of consanguinity than Europeans and we therefore explored the role of recessively acting variants, which replicated the HLA locus (rs9271850, P = 3.7 x 10(-23)) and suggested a role of additional four loci. To our knowledge, this is the first replication study of CeD variants in a non-European population.

引用

页码：530 / 535

页数：6

共 63 条

[51] Chromosome 7p11.2 (EGFR) variation influences glioma risk [J].

Sanson, Marc ;

Hosking, Fay J. ;

Shete, Sanjay ;

Zelenika, Diana ;

Dobbins, Sara E. ;

Ma, Yussanne ;

Enciso-Mora, Victor ;

Idbaih, Ahmed ;

Delattre, Jean-Yves ;

Hoang-Xuan, Khe ;

Marie, Yannick ;

Boisselier, Blandine ;

Carpentier, Catherine ;

Wang, Xiao-Wei ;

Di Stefano, Anna Luisa ;

Labussiere, Marianne ;

Gousias, Konstantinos ;

Schramm, Johannes ;

Boland, Anne ;

Lechner, Doris ;

Gut, Ivo ;

Armstrong, Georgina ;

Liu, Yanhong ;

Yu, Robert ;

Lau, Ching ;

Di Bernardo, Maria Chiara ;

Robertson, Lindsay B. ;

Muir, Kenneth ;

Hepworth, Sarah ;

Swerdlow, Anthony ;

Schoemaker, Minouk J. ;

Wichmann, H. -Erich ;

Mueller, Martina ;

Schreiber, Stefan ;

Franke, Andre ;

Moebus, Susanne ;

Eisele, Lewin ;

Foersti, Asta ;

Hemminki, Kari ;

Lathrop, Mark ;

Bondy, Melissa ;

Houlston, Richard S. ;

Simon, Matthias .

HUMAN MOLECULAR GENETICS, 2011, 20 (14) :2897-2904

[52] Genome-wide association study identifies five susceptibility loci for glioma [J].

Shete, Sanjay ;

Hosking, Fay J. ;

Robertson, Lindsay B. ;

Dobbins, Sara E. ;

Sanson, Marc ;

Malmer, Beatrice ;

Simon, Matthias ;

Marie, Yannick ;

Boisselier, Blandine ;

Delattre, Jean-Yves ;

Hoang-Xuan, Khe ;

El Hallani, Soufiane ;

Idbaih, Ahmed ;

Zelenika, Diana ;

Andersson, Ulrika ;

Henriksson, Roger ;

Bergenheim, A. Tommy ;

Feychting, Maria ;

Lonn, Stefan ;

Ahlbom, Anders ;

Schramm, Johannes ;

Linnebank, Michael ;

Hemminki, Kari ;

Kumar, Rajiv ;

Hepworth, Sarah J. ;

Price, Amy ;

Armstrong, Georgina ;

Liu, Yanhong ;

Gu, Xiangjun ;

Yu, Robert ;

Lau, Ching ;

Schoemaker, Minouk ;

Muir, Kenneth ;

Swerdlow, Anthony ;

Lathrop, Mark ;

Bondy, Melissa ;

Houlston, Richard S. .

NATURE GENETICS, 2009, 41 (08) :899-U54

[53] Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 [J].

Sklar, Pamela ;

Ripke, Stephan ;

Scott, Laura J. ;

Andreassen, Ole A. ;

Cichon, Sven ;

Craddock, Nick ;

Edenberg, Howard J. ;

Nurnberger, John I., Jr. ;

Rietschel, Marcella ;

Blackwood, Douglas ;

Corvin, Aiden ;

Flickinger, Matthew ;

Guan, Weihua ;

Mattingsdal, Morten ;

McQuillin, Andrew ;

Kwan, Phoenix ;

Wienker, Thomas F. ;

Daly, Mark ;

Dudbridge, Frank ;

Holmans, Peter A. ;

Lin, Danyu ;

Burmeister, Margit ;

Greenwood, Tiffany A. ;

Hamshere, Marian L. ;

Muglia, Pierandrea ;

Smith, Erin N. ;

Zandi, Peter P. ;

Nievergelt, Caroline M. ;

McKinney, Rebecca ;

Shilling, Paul D. ;

Schork, Nicholas J. ;

Bloss, Cinnamon S. ;

Foroud, Tatiana ;

Koller, Daniel L. ;

Gershon, Elliot S. ;

Liu, Chunyu ;

Badner, Judith A. ;

Scheftner, William A. ;

Lawson, William B. ;

Nwulia, Evaristus A. ;

Hipolito, Maria ;

Coryell, William ;

Rice, John ;

Byerley, William ;

McMahon, Francis J. ;

Schulze, Thomas G. ;

Berrettini, Wade ;

Lohoff, Falk W. ;

Potash, James B. ;

Mahon, Pamela B. .

NATURE GENETICS, 2011, 43 (10) :977-U162

[54] Prevalence, human leukocyte antigen typing and strategy for screening among Asian first-degree relatives of children with celiac disease [J].

Srivastava, Anshu ;

Yachha, Surender Kumar ;

Mathias, Amrita ;

Parveen, Farah ;

Poddar, Ujjal ;

Agrawal, Suraksha .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2010, 25 (02) :319-324

[55] Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci [J].

Stahl, Eli A. ;

Raychaudhuri, Soumya ;

Remmers, Elaine F. ;

Xie, Gang ;

Eyre, Stephen ;

Thomson, Brian P. ;

Li, Yonghong ;

Kurreeman, Fina A. S. ;

Zhernakova, Alexandra ;

Hinks, Anne ;

Guiducci, Candace ;

Chen, Robert ;

Alfredsson, Lars ;

Amos, Christopher I. ;

Ardlie, Kristin G. ;

Barton, Anne ;

Bowes, John ;

Brouwer, Elisabeth ;

Burtt, Noel P. ;

Catanese, Joseph J. ;

Coblyn, Jonathan ;

Coenen, Marieke J. H. ;

Costenbader, Karen H. ;

Criswell, Lindsey A. ;

Crusius, J. Bart A. ;

Cui, Jing ;

de Bakker, Paul I. W. ;

De Jager, Philip L. ;

Ding, Bo ;

Emery, Paul ;

Flynn, Edward ;

Harrison, Pille ;

Hocking, Lynne J. ;

Huizinga, Tom W. J. ;

Kastner, Daniel L. ;

Ke, Xiayi ;

Lee, Annette T. ;

Liu, Xiangdong ;

Martin, Paul ;

Morgan, Ann W. ;

Padyukov, Leonid ;

Posthumus, Marcel D. ;

Radstake, Timothy R. D. J. ;

Reid, David M. ;

Seielstad, Mark ;

Seldin, Michael F. ;

Shadick, Nancy A. ;

Steer, Sophia ;

Tak, Paul P. ;

Thomson, Wendy .

NATURE GENETICS, 2010, 42 (06) :508-U56

[56] Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21 [J].

Tabassum, Rubina ;

Chauhan, Ganesh ;

Dwivedi, Om Prakash ;

Mahajan, Anubha ;

Jaiswal, Alok ;

Kaur, Ismeet ;

Bandesh, Khushdeep ;

Singh, Tejbir ;

Mathai, Benan John ;

Pandey, Yogesh ;

Chidambaram, Manickam ;

Sharma, Amitabh ;

Chavali, Sreenivas ;

Sengupta, Shantanu ;

Ramakrishnan, Lakshmi ;

Venkatesh, Pradeep ;

Aggarwal, Sanjay K. ;

Ghosh, Saurabh ;

Prabhakaran, Dorairaj ;

Srinath, Reddy K. ;

Saxena, Madhukar ;

Banerjee, Monisha ;

Mathur, Sandeep ;

Bhansali, Anil ;

Shah, Viral N. ;

Madhu, Sri Venkata ;

Marwaha, Raman K. ;

Basu, Analabha ;

Scaria, Vinod ;

McCarthy, Mark I. ;

Venkatesan, Radha ;

Mohan, Viswanathan ;

Tandon, Nikhil ;

Bharadwaj, Dwaipayan .

DIABETES, 2013, 62 (03) :977-986

[57] Biological, clinical and population relevance of 95 loci for blood lipids [J].

Teslovich, Tanya M. ;

Musunuru, Kiran ;

Smith, Albert V. ;

Edmondson, Andrew C. ;

Stylianou, Ioannis M. ;

Koseki, Masahiro ;

Pirruccello, James P. ;

Ripatti, Samuli ;

Chasman, Daniel I. ;

Willer, Cristen J. ;

Johansen, Christopher T. ;

Fouchier, Sigrid W. ;

Isaacs, Aaron ;

Peloso, Gina M. ;

Barbalic, Maja ;

Ricketts, Sally L. ;

Bis, Joshua C. ;

Aulchenko, Yurii S. ;

Thorleifsson, Gudmar ;

Feitosa, Mary F. ;

Chambers, John ;

Orho-Melander, Marju ;

Melander, Olle ;

Johnson, Toby ;

Li, Xiaohui ;

Guo, Xiuqing ;

Li, Mingyao ;

Cho, Yoon Shin ;

Go, Min Jin ;

Kim, Young Jin ;

Lee, Jong-Young ;

Park, Taesung ;

Kim, Kyunga ;

Sim, Xueling ;

Ong, Rick Twee-Hee ;

Croteau-Chonka, Damien C. ;

Lange, Leslie A. ;

Smith, Joshua D. ;

Song, Kijoung ;

Zhao, Jing Hua ;

Yuan, Xin ;

Luan, Jian'an ;

Lamina, Claudia ;

Ziegler, Andreas ;

Zhang, Weihua ;

Zee, Robert Y. L. ;

Wright, Alan F. ;

Witteman, Jacqueline C. M. ;

Wilson, James F. ;

Willemsen, Gonneke .

NATURE, 2010, 466 (7307) :707-713

[58] Increased prevalence of celiac disease without gastrointestinal symptoms in adults MICA 5.1 homozygous subjects from the Campania area [J].

Tinto, N. ;

Ciacci, C. ;

Calcagno, G. ;

Gennarelli, D. ;

Spampanato, A. ;

Farinaro, E. ;

Tortora, R. ;

Sacchetti, L. .

DIGESTIVE AND LIVER DISEASE, 2008, 40 (04) :248-252

[59] Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes [J].

Todd, John A. ;

Walker, Neil M. ;

Cooper, Jason D. ;

Smyth, Deborah J. ;

Downes, Kate ;

Plagnol, Vincent ;

Bailey, Rebecca ;

Nejentsev, Sergey ;

Field, Sarah F. ;

Payne, Felicity ;

Lowe, Christopher E. ;

Szeszko, Jeffrey S. ;

Hafler, Jason P. ;

Zeitels, Lauren ;

Yang, Jennie H. M. ;

Vella, Adrian ;

Nutland, Sarah ;

Stevens, Helen E. ;

Schuilenburg, Helen ;

Coleman, Gillian ;

Maisuria, Meeta ;

Meadows, William ;

Smink, Luc J. ;

Healy, Barry ;

Burren, Oliver S. ;

Lam, Alex A. C. ;

Ovington, Nigel R. ;

Allen, James ;

Adlem, Ellen ;

Leung, Hin-Tak ;

Wallace, Chris ;

Howson, Joanna M. M. ;

Guja, Cristian ;

Ionescu-Tirgoviste, Constantin ;

Simmonds, Matthew J. ;

Heward, Joanne M. ;

Gough, Stephen C. L. ;

Dunger, David B. ;

Wicker, Linda S. ;

Clayton, David G. .

NATURE GENETICS, 2007, 39 (07) :857-864

[60] Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease [J].

Trynka, Gosia ;

Hunt, Karen A. ;

Bockett, Nicholas A. ;

Romanos, Jihane ;

Mistry, Vanisha ;

Szperl, Agata ;

Bakker, Sjoerd F. ;

Bardella, Maria Teresa ;

Bhaw-Rosun, Leena ;

Castillejo, Gemma ;

de la Concha, Emilio G. ;

de Almeida, Rodrigo Coutinho ;

Dias, Kerith-Rae M. ;

van Diemen, Cleo C. ;

Dubois, Patrick C. A. ;

Duerr, Richard H. ;

Edkins, Sarah ;

Franke, Lude ;

Fransen, Karin ;

Gutierrez, Javier ;

Heap, Graham A. R. ;

Hrdlickova, Barbara ;

Hunt, Sarah ;

Plaza Izurieta, Leticia ;

Izzo, Valentina ;

Joosten, Leo A. B. ;

Langford, Cordelia ;

Mazzilli, Maria Cristina ;

Mein, Charles A. ;

Midah, Vandana ;

Mitrovic, Mitja ;

Mora, Barbara ;

Morelli, Marinita ;

Nutland, Sarah ;

Nunez, Concepcion ;

Onengut-Gumuscu, Suna ;

Pearce, Kerra ;

Platteel, Mathieu ;

Polanco, Isabel ;

Potter, Simon ;

Ribes-Koninckx, Carmen ;

Ricano-Ponce, Isis ;

Rich, Stephen S. ;

Rybak, Anna ;

Luis Santiago, Jose ;

Senapati, Sabyasachi ;

Sood, Ajit ;

Szajewska, Hania ;

Troncone, Riccardo ;

Varade, Jezabel .

NATURE GENETICS, 2011, 43 (12) :1193-U45

← 1 2 3 4 5 6 7 →

共 63 条

[51] Chromosome 7p11.2 (EGFR) variation influences glioma risk [J].

Sanson, Marc ;

Hosking, Fay J. ;

Shete, Sanjay ;

Zelenika, Diana ;

Dobbins, Sara E. ;

Ma, Yussanne ;

Enciso-Mora, Victor ;

Idbaih, Ahmed ;

Delattre, Jean-Yves ;

Hoang-Xuan, Khe ;

Marie, Yannick ;

Boisselier, Blandine ;

Carpentier, Catherine ;

Wang, Xiao-Wei ;

Di Stefano, Anna Luisa ;

Labussiere, Marianne ;

Gousias, Konstantinos ;

Schramm, Johannes ;

Boland, Anne ;

Lechner, Doris ;

Gut, Ivo ;

Armstrong, Georgina ;

Liu, Yanhong ;

Yu, Robert ;

Lau, Ching ;

Di Bernardo, Maria Chiara ;

Robertson, Lindsay B. ;

Muir, Kenneth ;

Hepworth, Sarah ;

Swerdlow, Anthony ;

Schoemaker, Minouk J. ;

Wichmann, H. -Erich ;

Mueller, Martina ;

Schreiber, Stefan ;

Franke, Andre ;

Moebus, Susanne ;

Eisele, Lewin ;

Foersti, Asta ;

Hemminki, Kari ;

Lathrop, Mark ;

Bondy, Melissa ;

Houlston, Richard S. ;

Simon, Matthias .

HUMAN MOLECULAR GENETICS, 2011, 20 (14) :2897-2904

[52] Genome-wide association study identifies five susceptibility loci for glioma [J].

Shete, Sanjay ;

Hosking, Fay J. ;

Robertson, Lindsay B. ;

Dobbins, Sara E. ;

Sanson, Marc ;

Malmer, Beatrice ;

Simon, Matthias ;

Marie, Yannick ;

Boisselier, Blandine ;

Delattre, Jean-Yves ;

Hoang-Xuan, Khe ;

El Hallani, Soufiane ;

Idbaih, Ahmed ;

Zelenika, Diana ;

Andersson, Ulrika ;

Henriksson, Roger ;

Bergenheim, A. Tommy ;

Feychting, Maria ;

Lonn, Stefan ;

Ahlbom, Anders ;

Schramm, Johannes ;

Linnebank, Michael ;

Hemminki, Kari ;

Kumar, Rajiv ;

Hepworth, Sarah J. ;

Price, Amy ;

Armstrong, Georgina ;

Liu, Yanhong ;

Gu, Xiangjun ;

Yu, Robert ;

Lau, Ching ;

Schoemaker, Minouk ;

Muir, Kenneth ;

Swerdlow, Anthony ;

Lathrop, Mark ;

Bondy, Melissa ;

Houlston, Richard S. .

NATURE GENETICS, 2009, 41 (08) :899-U54

[53] Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 [J].

Sklar, Pamela ;

Ripke, Stephan ;

Scott, Laura J. ;

Andreassen, Ole A. ;

Cichon, Sven ;

Craddock, Nick ;

Edenberg, Howard J. ;

Nurnberger, John I., Jr. ;

Rietschel, Marcella ;

Blackwood, Douglas ;

Corvin, Aiden ;

Flickinger, Matthew ;

Guan, Weihua ;

Mattingsdal, Morten ;

McQuillin, Andrew ;

Kwan, Phoenix ;

Wienker, Thomas F. ;

Daly, Mark ;

Dudbridge, Frank ;

Holmans, Peter A. ;

Lin, Danyu ;

Burmeister, Margit ;

Greenwood, Tiffany A. ;

Hamshere, Marian L. ;

Muglia, Pierandrea ;

Smith, Erin N. ;

Zandi, Peter P. ;

Nievergelt, Caroline M. ;

McKinney, Rebecca ;

Shilling, Paul D. ;

Schork, Nicholas J. ;

Bloss, Cinnamon S. ;

Foroud, Tatiana ;

Koller, Daniel L. ;

Gershon, Elliot S. ;

Liu, Chunyu ;

Badner, Judith A. ;

Scheftner, William A. ;

Lawson, William B. ;

Nwulia, Evaristus A. ;

Hipolito, Maria ;

Coryell, William ;

Rice, John ;

Byerley, William ;

McMahon, Francis J. ;

Schulze, Thomas G. ;

Berrettini, Wade ;

Lohoff, Falk W. ;

Potash, James B. ;

Mahon, Pamela B. .

NATURE GENETICS, 2011, 43 (10) :977-U162

[54] Prevalence, human leukocyte antigen typing and strategy for screening among Asian first-degree relatives of children with celiac disease [J].

Srivastava, Anshu ;

Yachha, Surender Kumar ;

Mathias, Amrita ;

Parveen, Farah ;

Poddar, Ujjal ;

Agrawal, Suraksha .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2010, 25 (02) :319-324

[55] Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci [J].

Stahl, Eli A. ;

Raychaudhuri, Soumya ;

Remmers, Elaine F. ;

Xie, Gang ;

Eyre, Stephen ;

Thomson, Brian P. ;

Li, Yonghong ;

Kurreeman, Fina A. S. ;

Zhernakova, Alexandra ;

Hinks, Anne ;

Guiducci, Candace ;

Chen, Robert ;

Alfredsson, Lars ;

Amos, Christopher I. ;

Ardlie, Kristin G. ;

Barton, Anne ;

Bowes, John ;

Brouwer, Elisabeth ;

Burtt, Noel P. ;

Catanese, Joseph J. ;

Coblyn, Jonathan ;

Coenen, Marieke J. H. ;

Costenbader, Karen H. ;

Criswell, Lindsey A. ;

Crusius, J. Bart A. ;

Cui, Jing ;

de Bakker, Paul I. W. ;

De Jager, Philip L. ;

Ding, Bo ;

Emery, Paul ;

Flynn, Edward ;

Harrison, Pille ;

Hocking, Lynne J. ;

Huizinga, Tom W. J. ;

Kastner, Daniel L. ;

Ke, Xiayi ;

Lee, Annette T. ;

Liu, Xiangdong ;

Martin, Paul ;

Morgan, Ann W. ;

Padyukov, Leonid ;

Posthumus, Marcel D. ;

Radstake, Timothy R. D. J. ;

Reid, David M. ;

Seielstad, Mark ;

Seldin, Michael F. ;

Shadick, Nancy A. ;

Steer, Sophia ;

Tak, Paul P. ;

Thomson, Wendy .

NATURE GENETICS, 2010, 42 (06) :508-U56

[56] Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21 [J].

Tabassum, Rubina ;

Chauhan, Ganesh ;

Dwivedi, Om Prakash ;

Mahajan, Anubha ;

Jaiswal, Alok ;

Kaur, Ismeet ;

Bandesh, Khushdeep ;

Singh, Tejbir ;

Mathai, Benan John ;

Pandey, Yogesh ;

Chidambaram, Manickam ;

Sharma, Amitabh ;

Chavali, Sreenivas ;

Sengupta, Shantanu ;

Ramakrishnan, Lakshmi ;

Venkatesh, Pradeep ;

Aggarwal, Sanjay K. ;

Ghosh, Saurabh ;

Prabhakaran, Dorairaj ;

Srinath, Reddy K. ;

Saxena, Madhukar ;

Banerjee, Monisha ;

Mathur, Sandeep ;

Bhansali, Anil ;

Shah, Viral N. ;

Madhu, Sri Venkata ;

Marwaha, Raman K. ;

Basu, Analabha ;

Scaria, Vinod ;

McCarthy, Mark I. ;

Venkatesan, Radha ;

Mohan, Viswanathan ;

Tandon, Nikhil ;

Bharadwaj, Dwaipayan .

DIABETES, 2013, 62 (03) :977-986

[57] Biological, clinical and population relevance of 95 loci for blood lipids [J].

Teslovich, Tanya M. ;

Musunuru, Kiran ;

Smith, Albert V. ;

Edmondson, Andrew C. ;

Stylianou, Ioannis M. ;

Koseki, Masahiro ;

Pirruccello, James P. ;

Ripatti, Samuli ;

Chasman, Daniel I. ;

Willer, Cristen J. ;

Johansen, Christopher T. ;

Fouchier, Sigrid W. ;

Isaacs, Aaron ;

Peloso, Gina M. ;

Barbalic, Maja ;

Ricketts, Sally L. ;

Bis, Joshua C. ;

Aulchenko, Yurii S. ;

Thorleifsson, Gudmar ;

Feitosa, Mary F. ;

Chambers, John ;

Orho-Melander, Marju ;

Melander, Olle ;

Johnson, Toby ;

Li, Xiaohui ;

Guo, Xiuqing ;

Li, Mingyao ;

Cho, Yoon Shin ;

Go, Min Jin ;

Kim, Young Jin ;

Lee, Jong-Young ;

Park, Taesung ;

Kim, Kyunga ;

Sim, Xueling ;

Ong, Rick Twee-Hee ;

Croteau-Chonka, Damien C. ;

Lange, Leslie A. ;

Smith, Joshua D. ;

Song, Kijoung ;

Zhao, Jing Hua ;

Yuan, Xin ;

Luan, Jian'an ;

Lamina, Claudia ;

Ziegler, Andreas ;

Zhang, Weihua ;

Zee, Robert Y. L. ;

Wright, Alan F. ;

Witteman, Jacqueline C. M. ;

Wilson, James F. ;

Willemsen, Gonneke .

NATURE, 2010, 466 (7307) :707-713

[58] Increased prevalence of celiac disease without gastrointestinal symptoms in adults MICA 5.1 homozygous subjects from the Campania area [J].

Tinto, N. ;

Ciacci, C. ;

Calcagno, G. ;

Gennarelli, D. ;

Spampanato, A. ;

Farinaro, E. ;

Tortora, R. ;

Sacchetti, L. .

DIGESTIVE AND LIVER DISEASE, 2008, 40 (04) :248-252

[59] Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes [J].

Todd, John A. ;

Walker, Neil M. ;

Cooper, Jason D. ;

Smyth, Deborah J. ;

Downes, Kate ;

Plagnol, Vincent ;

Bailey, Rebecca ;

Nejentsev, Sergey ;

Field, Sarah F. ;

Payne, Felicity ;

Lowe, Christopher E. ;

Szeszko, Jeffrey S. ;

Hafler, Jason P. ;

Zeitels, Lauren ;

Yang, Jennie H. M. ;

Vella, Adrian ;

Nutland, Sarah ;

Stevens, Helen E. ;

Schuilenburg, Helen ;

Coleman, Gillian ;

Maisuria, Meeta ;

Meadows, William ;

Smink, Luc J. ;

Healy, Barry ;

Burren, Oliver S. ;

Lam, Alex A. C. ;

Ovington, Nigel R. ;

Allen, James ;

Adlem, Ellen ;

Leung, Hin-Tak ;

Wallace, Chris ;

Howson, Joanna M. M. ;

Guja, Cristian ;

Ionescu-Tirgoviste, Constantin ;

Simmonds, Matthew J. ;

Heward, Joanne M. ;

Gough, Stephen C. L. ;

Dunger, David B. ;

Wicker, Linda S. ;

Clayton, David G. .

NATURE GENETICS, 2007, 39 (07) :857-864

[60] Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease [J].

Trynka, Gosia ;

Hunt, Karen A. ;

Bockett, Nicholas A. ;

Romanos, Jihane ;

Mistry, Vanisha ;

Szperl, Agata ;

Bakker, Sjoerd F. ;

Bardella, Maria Teresa ;

Bhaw-Rosun, Leena ;

Castillejo, Gemma ;

de la Concha, Emilio G. ;

de Almeida, Rodrigo Coutinho ;

Dias, Kerith-Rae M. ;

van Diemen, Cleo C. ;

Dubois, Patrick C. A. ;

Duerr, Richard H. ;

Edkins, Sarah ;

Franke, Lude ;

Fransen, Karin ;

Gutierrez, Javier ;

Heap, Graham A. R. ;

Hrdlickova, Barbara ;

Hunt, Sarah ;

Plaza Izurieta, Leticia ;

Izzo, Valentina ;

Joosten, Leo A. B. ;

Langford, Cordelia ;

Mazzilli, Maria Cristina ;

Mein, Charles A. ;

Midah, Vandana ;

Mitrovic, Mitja ;

Mora, Barbara ;

Morelli, Marinita ;

Nutland, Sarah ;

Nunez, Concepcion ;

Onengut-Gumuscu, Suna ;

Pearce, Kerra ;

Platteel, Mathieu ;

Polanco, Isabel ;

Potter, Simon ;

Ribes-Koninckx, Carmen ;

Ricano-Ponce, Isis ;

Rich, Stephen S. ;

Rybak, Anna ;

Luis Santiago, Jose ;

Senapati, Sabyasachi ;

Sood, Ajit ;

Szajewska, Hania ;

Troncone, Riccardo ;

Varade, Jezabel .

NATURE GENETICS, 2011, 43 (12) :1193-U45

← 1 2 3 4 5 6 7 →