Safety, tolerability, and efficacy of a glucose-insulin potassium-magnesium-carnitine solution in acute myocardial infarction

被引：12
作者：
Arsenian, MA [1 ]
New, PS [1 ]
Cafasso, CM [1 ]
机构：
[1] ADDISON GILBERT HOSP, GLOUCESTER, MA USA
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 1996年 / 78卷 / 04期
关键词：
D O I：
10.1016/0002-9149(97)00001-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fifty-four patients with acute myocardial infarction were treated with a front-load, 15-hour infusion of hypertonic glucose, insulin, potassium, magnesium, and L-carnitine in addition to usual therapy. This metabolic solution was well tolerated, free of serious side effects, and reduced the incidence of morbid events.
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页码：476 / +
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共 24 条
[1]  
[Anonymous], 1995, LANCET, V345, P669
[2]   RANDOMIZED TRIALS OF MAGNESIUM IN ACUTE MYOCARDIAL-INFARCTION - BIG NUMBERS DO NOT TELL THE WHOLE STORY [J].
ANTMAN, EM .
AMERICAN JOURNAL OF CARDIOLOGY, 1995, 75 (05) :391-393
[3]   DETERMINANTS OF A PROTECTIVE EFFECT OF GLUCOSE AND INSULIN ON THE ISCHEMIC MYOCARDIUM - EFFECTS ON CONTRACTILE FUNCTION, DIASTOLIC COMPLIANCE, METABOLISM, AND ULTRASTRUCTURE DURING ISCHEMIA AND REPERFUSION [J].
APSTEIN, CS ;
GRAVINO, FN ;
HAUDENSCHILD, CC .
CIRCULATION RESEARCH, 1983, 52 (05) :515-526
[4]   BENEFICIAL EFFECT OF CARNITINE ON MECHANICAL RECOVERY OF RAT HEARTS REPERFUSED AFTER A TRANSIENT PERIOD OF GLOBAL-ISCHEMIA IS ACCOMPANIED BY A STIMULATION OF GLUCOSE-OXIDATION [J].
BRODERICK, TL ;
QUINNEY, HA ;
BARKER, CC ;
LOPASCHUK, GD .
CIRCULATION, 1993, 87 (03) :972-981
[5]  
DAVINI P, 1992, DRUG EXP CLIN RES, V18, P355
[6]   EFFECTS OF L-CARNITINE ADMINISTRATION ON LEFT-VENTRICULAR REMODELING AFTER ACUTE ANTERIOR MYOCARDIAL-INFARCTION - THE L-CARNITINE-ECOCARDIOGRAFIA-DIGITALIZZATA-INFARTO-MIOCARDICO (CEDIM) TRIAL [J].
ILICETO, S ;
SCRUTINIO, D ;
BRUZZI, P ;
DAMBROSIO, G ;
BONI, L ;
DIBLASE, M ;
BIASCO, G ;
HUGENHOLTZ, PG ;
RIZZON, P .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 26 (02) :380-387
[7]   AN EXPERIMENTAL-MODEL EXAMINING THE ROLE OF MAGNESIUM IN THE THERAPY OF ACUTE MYOCARDIAL-INFARCTION [J].
LEOR, J ;
KLONER, RA .
AMERICAN JOURNAL OF CARDIOLOGY, 1995, 75 (17) :1292-1293
[8]   RANDOMIZED TRIAL OF INSULIN-GLUCOSE INFUSION FOLLOWED BY SUBCUTANEOUS INSULIN-TREATMENT IN DIABETIC-PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION (DIGAMI STUDY) - EFFECTS ON MORTALITY AT 1 YEAR [J].
MALMBERG, K ;
RYDEN, L ;
EFENDIC, S ;
HERLITZ, J ;
NICOL, P ;
WALDENSTROM, A ;
WEDEL, H ;
WELIN, L .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 26 (01) :57-65
[9]   EFFECT OF GLUCOSE-INSULIN-POTASSIUM INFUSION ON MYOCARDIAL-INFARCTION FOLLOWING EXPERIMENTAL CORONARY-ARTERY OCCLUSION [J].
MAROKO, PR ;
LIBBY, P ;
COVELL, JW ;
BRAUNWALD, E ;
BLOOR, CM ;
SOBEL, BE ;
SHELL, WE ;
SYBERS, HD .
CIRCULATION, 1972, 45 (06) :1160-+
[10]   SEVERE HYPOPHOSPHATEMIA INDUCED BY GLUCOSE INSULIN POTASSIUM THERAPY - A CASE-REPORT AND PROPOSAL FOR ALTERED PROTOCOL [J].
MARWICK, TH ;
WOODHOUSE, SP .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 1988, 18 (03) :327-330
123