The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism

被引：37
作者：
Zhang, Ye [1 ]
Yan, Wen-Ting [1 ]
Yang, Ze-Yu [2 ]
Li, Yan-Ling [1 ]
Tan, Xuan-Ni [1 ]
Jiang, Jun [1 ]
Zhang, Yi [1 ]
Qi, Xiao-Wei [1 ]
机构：
[1] Army Med Univ, Southwest Hosp, Breast & Thyroid Surg, Gaotanyan St 29, Chongqing 400038, Peoples R China
[2] Univ Chinese Acad Sci, Chongqing Gen Hosp, Breast & Thyroid Surg, Chongqing 400013, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2020年 / 16卷 / 08期
基金：
中国国家自然科学基金;
关键词：
WT1; breast neoplasms; prognosis; carcinogenesis; TUMOR SUPPRESSOR GENE; ESTROGEN-RECEPTOR-ALPHA; TRANSCRIPTIONAL REGULATION; WILMS-TUMOR-1; PROTEIN; DOWN-REGULATION; POOR-PROGNOSIS; EXPRESSION; ISOFORMS; GROWTH; PROLIFERATION;
D O I：
10.7150/ijbs.39958
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies have demonstrated that it can also play an oncogenic role in leukemia and various solid tumors. WT1 exerts biological functions with high tissue- and cell-specificity. This article reviews the relationship between WT1 and breast cancer from two aspects: (1) clinical application of WT1, including the relationship between expression of WT1 and prognosis of breast cancer patients, and its effectiveness as a target for comprehensive therapy of breast cancer; (2) the biological effects and molecular mechanisms of WT1 in the development and progression of breast cancer, including proliferation, apoptosis, invasion, and metastasis of breast cancer cells.
引用
收藏
页码：1474 / 1480
页数：7
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