The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism

被引：37

作者：

Zhang, Ye ^{[1
]}

Yan, Wen-Ting ^{[1
]}

Yang, Ze-Yu ^{[2
]}

Li, Yan-Ling ^{[1
]}

Tan, Xuan-Ni ^{[1
]}

Jiang, Jun ^{[1
]}

Zhang, Yi ^{[1
]}

Qi, Xiao-Wei ^{[1
]}

机构：

[1] Army Med Univ, Southwest Hosp, Breast & Thyroid Surg, Gaotanyan St 29, Chongqing 400038, Peoples R China

[2] Univ Chinese Acad Sci, Chongqing Gen Hosp, Breast & Thyroid Surg, Chongqing 400013, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2020年 / 16卷 / 08期

基金：

中国国家自然科学基金;

关键词：

WT1; breast neoplasms; prognosis; carcinogenesis; TUMOR SUPPRESSOR GENE; ESTROGEN-RECEPTOR-ALPHA; TRANSCRIPTIONAL REGULATION; WILMS-TUMOR-1; PROTEIN; DOWN-REGULATION; POOR-PROGNOSIS; EXPRESSION; ISOFORMS; GROWTH; PROLIFERATION;

D O I：

10.7150/ijbs.39958

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies have demonstrated that it can also play an oncogenic role in leukemia and various solid tumors. WT1 exerts biological functions with high tissue- and cell-specificity. This article reviews the relationship between WT1 and breast cancer from two aspects: (1) clinical application of WT1, including the relationship between expression of WT1 and prognosis of breast cancer patients, and its effectiveness as a target for comprehensive therapy of breast cancer; (2) the biological effects and molecular mechanisms of WT1 in the development and progression of breast cancer, including proliferation, apoptosis, invasion, and metastasis of breast cancer cells.

引用

页码：1474 / 1480

页数：7

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