Variation at the GABAA Receptor Gene, Rho 1 (GABRR1) Associated With Susceptibility to Bipolar Schizoaffective Disorder

被引：15

作者：

Green, Elaine K. ^{[1
,2
]}

Grozeva, Detelina ^{[2
]}

Moskvina, Valentina

Hamshere, Marian L.

Jones, Ian R. ^{[2
]}

Jones, Lisa ^{[3
]}

Forty, Liz ^{[2
]}

Caesar, Sian ^{[3
]}

Gordon-Smith, Katherine ^{[3
]}

Fraser, Christine ^{[2
]}

Russell, Ellie ^{[2
]}

St Clair, David ^{[4
]}

Young, Allan H. ^{[5
,6
]}

Ferrier, Nicol ^{[5
]}

Farmer, Anne ^{[7
]}

McGuffin, Peter ^{[7
]}

Holmans, Peter A. ^{[2
]}

Owen, Michael J. ^{[2
]}

O'Donovan, Michael C. ^{[2
]}

Craddock, Nick ^{[2
]}

机构：

[1] Cardiff Univ, Dept Psychol Med, Sch Med, Biostat & Bioinformat Unit, Cardiff CF14 4XN, S Glam, Wales

[2] Cardiff Univ, Dept Psychol Med & Neurol, Sch Med, MRC,Ctr Neuropsychiat Genet & Genom, Cardiff CF14 4XN, S Glam, Wales

[3] Univ Birmingham, Dept Psychiat, Natl Ctr Mental Hlth, Birmingham, W Midlands, England

[4] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland

[5] Royal Victoria Infirm, Sch Neurol Neurobiol & Psychiat, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[6] UBC Inst Mental Hlth, Vancouver, BC, Canada

[7] Kings Coll London, SGDP, Inst Psychiat, London WC2R 2LS, England

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2010年 / 153B卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

bipolar disorder; schizoaffective disorder; GABA(A) receptor; genetics; GENOME-WIDE ASSOCIATION;

D O I：

10.1002/ajmg.b.31108

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P 0.052). (c) 2010 Wiley-Liss, Inc.

引用

页码：1347 / 1349

页数：3

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