The Positive and Negative Immunoregulatory Role of B7 Family: Promising Novel Targets in Gastric Cancer Treatment

被引：71

作者：

Bolandi, Nadia ^{[1
,2
]}

Derakhshani, Afshin ^{[1
,3
]}

Hemmat, Nima ^{[1
]}

Baghbanzadeh, Amir ^{[1
]}

Asadzadeh, Zahra ^{[1
]}

Afrashteh Nour, Mina ^{[1
,2
]}

Brunetti, Oronzo ^{[4
]}

Bernardini, Renato ^{[5
]}

Silvestris, Nicola ^{[4
,6
]}

Baradaran, Behzad ^{[1
,7
,8
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz 516615731, Iran

[2] Urmia Univ Med Sci, Dept Biochem, Fac Med, Orumiyeh 571478334, Iran

[3] IRCCS Ist Tumori Giovanni Paolo II, Lab Expt Pharmacol, I-70124 Bari, Italy

[4] Med Oncol Unit IRCCS Ist Tumori Giovanni Paolo II, I-70124 Bari, Italy

[5] Univ Catania, Dept Biomed & Biotechnol Sci, Via S Sofia 97, I-95100 Catania, Italy

[6] Univ Bari, Dept Biomed Sci & Human Oncol DIMO, I-70124 Bari, Italy

[7] Tabriz Univ Med Sci, Dept Immunol, Fac Med, Tabriz 516615731, Iran

[8] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz 516615731, Iran

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 19期

关键词：

B7; family; immune checkpoints; immunotherapy; gastric cancer; REGULATORY T-CELLS; IMMUNE CHECKPOINT INHIBITORS; COSTIMULATORY MOLECULE; B7-H3; EXPRESSION; DENDRITIC CELLS; RECEPTOR NKP30; CLINICAL-SIGNIFICANCE; MONOCLONAL-ANTIBODY; PROTEIN EXPRESSION; MURINE B7-H3;

D O I：

10.3390/ijms221910719

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer (GC), with a heterogeneous nature, is the third leading cause of death worldwide. Over the past few decades, stable reductions in the incidence of GC have been observed. However, due to the poor response to common treatments and late diagnosis, this cancer is still considered one of the lethal cancers. Emerging methods such as immunotherapy with immune checkpoint inhibitors (ICIs) have transformed the landscape of treatment for GC patients. There are presently eleven known members of the B7 family as immune checkpoint molecules: B7-1 (CD80), B7-2 (CD86), B7-H1 (PD-L1, CD274), B7-DC (PDCD1LG2, PD-L2, CD273), B7-H2 (B7RP1, ICOS-L, CD275), B7-H3 (CD276), B7-H4 (B7x, B7S1, Vtcn1), B7-H5 (VISTA, Gi24, DD1 alpha, Dies1 SISP1), B7-H6 (NCR3LG1), B7-H7 (HHLA2), and Ig-like domain-containing receptor 2 (ILDR2). Interaction of the B7 family of immune-regulatory ligands with the corresponding receptors resulted in the induction and inhibition of T cell responses by sending co-stimulatory and co-inhibitory signals, respectively. Manipulation of the signals provided by the B7 family has significant potential in the management of GC.

引用

页数：25

共 198 条

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