Immunotherapy and therapeutic vaccines for chronic HBV infection

被引：19
作者：
Lang-Meli, Julia [1 ,2 ]
Neumann-Haefelin, Christoph [1 ]
Thimme, Robert [1 ]
机构：
[1] Univ Hosp Freiburg, Dept Med 2, Med Ctr Univ Freiburg, Fac Med, Freiburg, Germany
[2] Univ Hosp Freiburg, IMM PACT Programm, Fac Med, Freiburg, Germany
来源：
CURRENT OPINION IN VIROLOGY | 2021年 / 51卷
关键词：
CHRONIC HEPATITIS-B; CD8(+) T-CELLS; 7 AGONIST GS-9620; SURFACE-ANTIGEN; RECEPTOR; DYSFUNCTION; VACCINATION; EFFICACY; SAFETY; TRIAL;
D O I：
10.1016/j.coviro.2021.10.002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Chronic hepatitis B virus (HBV) infection is a major global health burden causing severe complications like liver cirrhosis or hepatocellular carcinoma. Curative treatment options are lacking. Therefore, there is an urgent need for new therapeutic options. Immunotherapy with the goal to restore dysfunctional HBV-specific T cell immunity is an interesting new therapeutic strategy. Based on current evidence on dysfunction of the HBV-specific CD8(+) T cell response in chronic HBV infection, we will review the growing field of immunotherapeutic approaches for treatment of chronic HBV infection. The review will focus on therapies targeting T cells and will cover checkpoint inhibitors, T cell engineering, Toll-like receptor agonists and therapeutic vaccination.
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页码：1 / 9
页数：9
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