Transcriptome of the human retina, retinal pigmented epithelium and choroid

被引：46

作者：

Tian, Lifeng ^{[1
]}

Kazmierkiewicz, Krista L. ^{[2
]}

Bowman, Anita S. ^{[2
]}

Li, Mingyao ^{[3
]}

Curcio, Christine A. ^{[4
]}

Stambolian, Dwight E. ^{[2
]}

机构：

[1] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Ophthalmol, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[4] Univ Alabama Birmingham, Sch Med, Dept Ophthalmol, Birmingham, AL 35294 USA

来源：

GENOMICS | 2015年 / 105卷 / 5-6期

关键词：

Age-related macular degeneration; cDNA microarray; Glaucoma; Retina; Retinal pigmented epithelium; Choroid; RNA-Seq; Serial analysis of gene expression; Transcriptome; SUBRETINAL DRUSENOID DEPOSITS; GENE-EXPRESSION; RETICULAR PSEUDODRUSEN; SERIAL ANALYSIS; GRADING SYSTEM; HUMAN MACULA; RNA; GENOMICS; EYES; REPRODUCIBILITY;

D O I：

10.1016/j.ygeno.2015.01.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The retina and its adjacent supporting tissues - retinal pigmented epithelium (RPE) and choroid - are critical structures in human eyes required for normal visual perception. Abnormal changes in these layers have been implicated in diseases such as age-related macular degeneration and glaucoma. With the advent of high-throughput methods, such as serial analysis of gene expression, cDNA microarray, and RNA sequencing, there is unprecedented opportunity to facilitate our understanding of the normal retina, RPE, and choroid. This information can be used to identify dysfunction in age-related macular degeneration and glaucoma. In this review, we describe the current status in our understanding of these transcriptomes through the use of high-throughput techniques. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：253 / 264

页数：12

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