Interleukin-22: Immunobiology and Pathology

被引：663
作者：
Dudakov, Jarrod A. [1 ,3 ]
Hanash, Alan M. [2 ]
van den Brink, Marcel R. M. [1 ,2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
[3] Monash Univ, Dept Anat & Dev Biol, Melbourne, Vic 3800, Australia
来源：
ANNUAL REVIEW OF IMMUNOLOGY VOL 33 | 2015年 / 33卷
关键词：
interleukin-22; epithelial cells; tissue regeneration; INNATE LYMPHOID-CELLS; ARYL-HYDROCARBON RECEPTOR; ROR-GAMMA-T; NATURAL-KILLER-CELLS; TISSUE-INDUCER CELLS; TRANSCRIPTION FACTOR GATA3; VERSUS-HOST-DISEASE; INVARIANT NKT CELLS; NEGATIVE PROGNOSTIC INDICATOR; INTESTINAL EPITHELIAL-CELLS;
D O I：
10.1146/annurev-immunol-032414-112123
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by helper (Th) 17 cells, gamma delta cells, NKT cells, and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues, including the intestines, lung, liver, kidney, thymus, pancreas. and skin. IL-22 primarily targets nonhematopoietic epithelial and stromal cells, where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.
引用
收藏
页码：747 / 785
页数：39
相关论文
共 398 条
  • [51] Induction of secondary and tertiary lymphoid structures in the skin
    Cupedo, T
    Jansen, W
    Kraal, G
    Mebius, RE
    [J]. IMMUNITY, 2004, 21 (05) : 655 - 667
  • [52] Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
    Cupedo, Tom
    Crellin, Natasha K.
    Papazian, Natalie
    Rombouts, Elwin J.
    Weijer, Kees
    Grogan, Jane L.
    Fibbe, Willem E.
    Cornelissen, Jan J.
    Spits, Hergen
    [J]. NATURE IMMUNOLOGY, 2009, 10 (01) : 66 - 74
  • [53] Solid cancers after bone marrow transplantation
    Curtis, RE
    Rowlings, PA
    Deeg, HJ
    Shriner, DA
    Socie, G
    Travis, LB
    Horowitz, MM
    Witherspoon, RP
    Hoover, RN
    Sobocinski, KA
    Fraumeni, JF
    Boice, JD
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (13) : 897 - 904
  • [54] Increased Serum Interleukin 22 in Patients with Rheumatoid Arthritis and Correlation with Disease Activity
    da Rocha, Laurindo Ferreira, Jr.
    Branco Pinto Duarte, Angela Luzia
    Dantas, Andrea Tavares
    Mariz, Henrique Ataide
    Pitta, Ivan da Rocha
    Galdino, Suely Lins
    da Rocha Pitta, Maira Galdino
    [J]. JOURNAL OF RHEUMATOLOGY, 2012, 39 (07) : 1320 - 1325
  • [55] T Cell-Derived IL-22 Amplifies IL-1β-Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes
    Dalmas, Elise
    Venteclef, Nicolas
    Caer, Charles
    Poitou, Christine
    Cremer, Isabelle
    Aron-Wisnewsky, Judith
    Lacroix-Desmazes, Sebastien
    Bayry, Jagadeesh
    Kaveri, Srinivas V.
    Clement, Karine
    Andre, Sebastien
    Guerre-Millo, Michele
    [J]. DIABETES, 2014, 63 (06) : 1966 - 1977
  • [56] The role of interleukin-22 in hepatitis C virus infection
    Dambacher, Julia
    Beigel, Florian
    Zitzmann, Kathrin
    Heeg, Malte H. J.
    Goeke, Burkhard
    Diepolder, Helmut M.
    Auernhammer, Christoph J.
    Brand, Stephan
    [J]. CYTOKINE, 2008, 41 (03) : 209 - 216
  • [57] Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion
    de Castro, Celia Peral
    Jones, Sarah A.
    Cheallaigh, Cliona Ni
    Hearnden, Claire A.
    Williams, Laura
    Winter, Jan
    Lavelle, Ed C.
    Mills, Kingston H. G.
    Harris, James
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 189 (08) : 4144 - 4153
  • [58] IL-22 defines a novel immune pathway of antifungal resistance
    De Luca, A.
    Zelante, T.
    D'Angelo, C.
    Zagarella, S.
    Fallarino, F.
    Spreca, A.
    Iannitti, R. G.
    Bonifazi, P.
    Renauld, J-C
    Bistoni, F.
    Puccetti, P.
    Romani, L.
    [J]. MUCOSAL IMMUNOLOGY, 2010, 3 (04) : 361 - 373
  • [59] Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22
    de Moura, Patricia Ribeiro
    Watanabe, Leandra
    Bleicher, Lucas
    Colau, Didier
    Dumoutier, Laure
    Lemaire, Muriel M.
    Renauld, Jean-Christophe
    Polikarpov, Igor
    [J]. FEBS LETTERS, 2009, 583 (07): : 1072 - 1077
  • [60] Association of esophageal candidiasis and squamous cell carcinoma
    Delsing, C. E.
    Bleeker-Rovers, C. P.
    van de Veerdonk, F. L.
    Tol, J.
    van der Meer, J. W. M.
    Kullberg, B. J.
    Netea, M. G.
    [J]. MEDICAL MYCOLOGY CASE REPORTS, 2012, 1 (01): : 5 - 8
12345678910