Interleukin-22: Immunobiology and Pathology

被引：663
作者：
Dudakov, Jarrod A. [1 ,3 ]
Hanash, Alan M. [2 ]
van den Brink, Marcel R. M. [1 ,2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
[3] Monash Univ, Dept Anat & Dev Biol, Melbourne, Vic 3800, Australia
来源：
ANNUAL REVIEW OF IMMUNOLOGY VOL 33 | 2015年 / 33卷
关键词：
interleukin-22; epithelial cells; tissue regeneration; INNATE LYMPHOID-CELLS; ARYL-HYDROCARBON RECEPTOR; ROR-GAMMA-T; NATURAL-KILLER-CELLS; TISSUE-INDUCER CELLS; TRANSCRIPTION FACTOR GATA3; VERSUS-HOST-DISEASE; INVARIANT NKT CELLS; NEGATIVE PROGNOSTIC INDICATOR; INTESTINAL EPITHELIAL-CELLS;
D O I：
10.1146/annurev-immunol-032414-112123
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by helper (Th) 17 cells, gamma delta cells, NKT cells, and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues, including the intestines, lung, liver, kidney, thymus, pancreas. and skin. IL-22 primarily targets nonhematopoietic epithelial and stromal cells, where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.
引用
收藏
页码：747 / 785
页数：39
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