Evaluation of the safety and protection efficacy of an attenuated genotype vii newcastle disease virus strain as a candidate vaccine

被引：4

作者：

Xu, Xiaohong ^{[1
,2
]}

Li, Jindou ^{[1
]}

Ding, Jiaxin ^{[1
]}

Yang, Mingxi ^{[1
]}

Xue, Cong ^{[4
]}

Wang, Jianzhong ^{[5
]}

Cong, Yanlong ^{[1
]}

Yin, Renfu ^{[1
]}

Qian, Jing ^{[3
]}

Jin, Ningyi ^{[2
]}

Ding, Zhuang ^{[1
]}

机构：

[1] Jilin Univ, Coll Vet Med, Lab Infect Dis, Key Lab Zoonosis Res,Minist Educ, Changchun 130062, Peoples R China

[2] Jilin Univ, Coll Basic Med Sci, Changchun 130021, Peoples R China

[3] Jiangsu Acad Agr Sci, Inst Vet Med, Minist Agr, Key Lab Vet Bioprod Engn, Nanjing 210014, Peoples R China

[4] Linyi Univ, Coll Agr & Forestry Sci, Linyi 276000, Shandong, Peoples R China

[5] Jilin Agr Univ, Engn Res Ctr Jilin Prov Anim Probiot, Coll Anim Sci & Technol, Changchun 130118, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2020年 / 139卷

基金：

中国国家自然科学基金;

关键词：

Newcastle disease; Genotype VII; Safety; Protective efficacy; Attenuated candidate vaccine; GEESE;

D O I：

10.1016/j.micpath.2019.103831

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Newcastle disease (ND) is a serious avian infectious disease, causing severe economic loss worldwide. Its prevention depends on comprehensive vaccination scheme against Newcastle disease virus (NDV). However, current vaccine strains are of different genotypes with prevalent circulating strains (genotype VII), with significant genetic distance. Our team previously generated a genotype matched attenuated NDV strain (rmNA-1). In this study, its safety and immunization efficacy were evaluated. Its lentogenic characteristic was stable for 25 generations in embryonated chicken eggs and for six generations in SPF chickens. Overdosed administration did not cause any clinical signs or pathogenic changes in chickens. As to its immunization effect, rmNA-1 stimulated a comparable serum NDV specific antibody level to a LaSota (genotype II) strain based commercial vaccine, and provided full protection against virulent genotype VII strain challenge, with significantly reduced virus shedding period.

引用

页数：8

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