High-resolution fast-tomography brain-imaging beamline at the Taiwan Photon Source

被引：8

作者：

Chen, Hsiang Hsin ^{[1
]}

Yang, Shun-Min ^{[1
]}

Yang, Kai-En ^{[1
]}

Chiu, Ching-Yu ^{[1
]}

Chang, Chia-Ju ^{[1
]}

Wang, Ya-Sian ^{[1
]}

Lee, Tsung-Tse ^{[1
]}

Huang, Yu-Fen ^{[1
]}

Chen, Yi-Yun ^{[1
]}

Petibois, Cyril ^{[1
]}

Chang, Shih-Hung ^{[2
]}

Cai, Xiaoqing ^{[3
]}

Low, Chian-Ming ^{[4
,5
]}

Tan, Francis Chee Kuan ^{[5
]}

Teo, Alvin ^{[6
]}

Tok, Eng Soon ^{[7
]}

Lim, Jae-Hong ^{[8
]}

Je, Jun-Ho ^{[9
]}

Kohmura, Yoshiki ^{[10
]}

Ishikawa, Tetsuya ^{[10
]}

Margaritondo, Giorgio ^{[11
,12
,13
]}

Hwu, Yeukuang ^{[1
]}

机构：

[1] Acad Sinica, Inst Phys, 128 Acad Rd Sec 2, Taipei 11529, Taiwan

[2] Natl Synchrotron Radiat Res Ctr, Hsinchu 30076, Taiwan

[3] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore

[5] Natl Univ Hlth Syst, Natl Univ Hosp, Dept Anaesthesia, Singapore, Singapore

[6] Nanyang Polytech, Sch Chem & Life Sci, Singapore, Singapore

[7] Natl Univ Singapore, Dept Phys, eMaGIC Lab, Singapore, Singapore

[8] Pohang Univ Sci & Technol, Pohang Accelerator Lab, Pohang 37673, Gyeongbuk, South Korea

[9] Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Pohang 37673, Gyeongbuk, South Korea

[10] RIKEN SPring 8 Ctr, Sayo, Hyogo 6795148, Japan

[11] Ecole Polytech Fed Lausanne, Fac Sci Base, CH-1015 Lausanne, Switzerland

[12] Natl Tsing Hua Univ, Brain Res Ctr, Hsinchu 30013, Taiwan

[13] Natl Cheng Kung Univ, Dept Engn Sci, Tainan 70100, Taiwan

来源：

JOURNAL OF SYNCHROTRON RADIATION | 2021年 / 28卷

关键词：

microtomography; high-resolution X-ray imaging; brain imaging; SYNCHROTRON-RADIATION; RAY; SHADOW;

D O I：

10.1107/S1600577521007633

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The new Brain Imaging Beamline (BIB) of the Taiwan Photon Source (TPS) has been commissioned and opened to users. The BIB and in particular its endstation are designed to take advantage of bright unmonochromatized synchrotron X-rays and target fast 3D imaging, similar to 1 ms exposure time plus very high similar to 0.3 mu m spatial resolution. A critical step in achieving the planned performances was the solution to the X-ray induced damaging problems of the detection system. High-energy photons were identified as their principal cause and were solved by combining tailored filters/attenuators and a high-energy cut-off mirror. This enabled the tomography acquisition throughput to reach >1 mm(3) min(-1), a critical performance for large-animal brain mapping and a vital mission of the beamline.

引用

页码：1662 / 1668

页数：7

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