Mesenchymal stem/stromal cell-based therapy for the treatment of rheumatoid arthritis: An update on preclinical studies

被引：34
作者：
Lopez-Santalla, Mercedes [1 ,2 ,3 ]
Bueren, Juan A. [1 ,2 ,3 ]
Garin, Marina, I [1 ,2 ,3 ]
机构：
[1] Ctr Invest Energet Medioambientales & Tecnol CIEM, Div Hematopoiet Innovat Therapies, Madrid, Spain
[2] Ctr Invest Biomed Red Enfermedades Raras CIBER ER, Madrid, Spain
[3] Inst Invest Sanitaria Fdn Jimenez Diaz IIS FJD UA, Adv Therapy Unit, Madrid, Spain
来源：
EBIOMEDICINE | 2021年 / 69卷
关键词：
Rheumatoid arthritis; Mesenchymal stem/stromal cells; Animal models; Protocols; Improvements in MSC-based therapy; COLLAGEN-INDUCED ARTHRITIS; STEM-CELLS; STROMAL CELLS; INFLAMMATION; TOLERANCE; DISEASE; MODELS; MICE;
D O I：
10.1016/j.ebiom.2021.103427
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and progressive joint destruction and is a primary cause of disability worldwide. Despite the existence of numerous anti-rheumatic drugs, a significant number of patients with RA do not respond or are intolerant to current treatments. Mesenchymal stem/stromal cell (MSCs) therapy represents a promising therapeutic tool to treat RA, mainly attributable to the immunomodulatory effects of these cells. This review comprises a comprehensive analysis of the scientific literature related to preclinical studies of MSC-based therapy in RA to analyse key aspects of current protocols as well as novel approaches which aim to improve the efficacy of MSC-based therapy. (C) 2021 The Authors. Published by Elsevier B.V.
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页数：9
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