Prevention of NAFLD-associated HCC: Role of lifestyle and chemoprevention

被引：96
作者：
Lange, Naomi F. [1 ,2 ]
Radu, Pompilia [1 ]
Dufour, Jean-Francois [1 ]
机构：
[1] Inselspital Bern, Univ Clin Visceral Surg & Med, Bern, Switzerland
[2] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland
来源：
JOURNAL OF HEPATOLOGY | 2021年 / 75卷 / 05期
关键词：
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Hepatocellular carcinoma; Prevention; Lifestyle; Diet; Physical activity; Coffee; Alcohol; Aspirin; Statins; Probiotics; FATTY LIVER-DISEASE; RANDOMIZED CONTROLLED-TRIAL; HEPATOCELLULAR-CARCINOMA; HEPATITIS-C; VIRAL-HEPATITIS; RISK-FACTORS; WEIGHT-LOSS; MEDITERRANEAN DIET; DIABETIC-PATIENTS; ALCOHOL-DRINKING;
D O I：
10.1016/j.jhep.2021.07.025
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In many countries worldwide, the burden of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing. Preventive strategies are needed to counteract this trend. In this review, we provide an overview of the evidence on preventive strategies in NAFLD-associated HCC. We consider the impact of lifestyle factors such as weight loss, physical activity, smoking, dietary patterns and food items, including coffee and alcohol, on both HCC and NAFLD/NASH. Furthermore, evidence on chemopreventive treatments, including aspirin, antidiabetic treatments and statins is summarised. The role of adjuvant therapies for tertiary prevention of HCC is briefly reviewed. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.
引用
收藏
页码：1217 / 1227
页数：11
相关论文
共 50 条
  • [31] Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention
    Huang, Daniel Q.
    El-Serag, Hashem B.
    Loomba, Rohit
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2021, 18 (04) : 223 - 238
  • [32] Synergism of Adipocytokine Profile and ADIPOQ/TNF-α Polymorphisms in NAFLD-associated MetS Predict Colorectal Liver Metastases Outgrowth
    Divella, Rosa
    Daniele, Antonella
    De Luca, Raffaele
    Mazzocca, Antonio
    Ruggieri, Eustachio
    Savino, Eufemia
    Casamassima, Porzia
    Simone, Michele
    Sabba, Carlo
    Paradiso, Angelo
    [J]. CANCER GENOMICS & PROTEOMICS, 2019, 16 (06) : 519 - 530
  • [33] Unique molecular characteristics of NAFLD-associated liver cancer accentuate β-catenin/TNFRSF19-mediated immune evasion
    Wong, Alissa Michelle
    Ding, Xiaofan
    Wong, Aikha Melissa
    Xu, Mingjing
    Zhang, Luyao
    Leung, Howard Ho-Wai
    Chan, Anthony Wing-Hung
    Song, Qi Xiu
    Kwong, Joseph
    Chan, Loucia Kit-Ying
    Man, Matthew
    He, Mian
    Chen, Jinna
    Zhang, Zhe
    You, Wenxing
    Lau, Coleen
    Yu, Allen
    Wei, Yingying
    Yuan, Yunfei
    Lai, Paul Bo-San
    Zhao, Jingmin
    Man, Kwan
    Yu, Jun
    Kahn, Michael
    Wong, Nathalie
    [J]. JOURNAL OF HEPATOLOGY, 2022, 77 (02) : 410 - 423
  • [34] The prevention of gestational diabetes mellitus (The role of lifestyle): a meta-analysis
    Abdullah H. Altemani
    Riyadh A. Alzaheb
    [J]. Diabetology & Metabolic Syndrome, 14
  • [35] Role of nutrition and healthy lifestyle, for individuals in primary prevention: recent data, gaps in evidence and future directions
    Metsovitis, Theodora
    Bernardi, Marco
    Bruckert, Eric
    Fogacci, Federica
    Cicero, Arrigo
    Garcia-Zamora, Sebastian
    Spadafora, Luigi
    Angoulvant, Denis
    Biondi-Zoccai, Giuseppe
    Sabouret, Pierre
    [J]. ARCHIVES OF MEDICAL SCIENCE, 2024, 20 (05) : 1385 - 1399
  • [36] The Role of Lifestyle Interventions in the Prevention of Gestational Diabetes
    Halperin, Ilana J.
    Feig, Denice S.
    [J]. CURRENT DIABETES REPORTS, 2014, 14 (01)
  • [37] NAFLD-Related HCC: How Should the Shift in Epidemiology Change Our Prevention and Surveillance Strategies?
    J. Andy Tau
    Aaron P. Thrift
    Fasiha Kanwal
    [J]. Current Hepatology Reports, 2017, 16 (1) : 26 - 32
  • [38] Role of Nutrition in the Etiopathogenesis and Prevention of Nonalcoholic Fatty Liver Disease (NAFLD) in a Group of Obese Adults
    Metro, Daniela
    Buda, Martina
    Manasseri, Luigi
    Corallo, Francesco
    Cardile, Davide
    Lo Buono, Viviana
    Quartarone, Angelo
    Bonanno, Lilla
    [J]. MEDICINA-LITHUANIA, 2023, 59 (03):
  • [39] The Role of Healthy Lifestyle in the Primordial Prevention of Cardiovascular Disease
    Claas, Steven A.
    Arnett, Donna K.
    [J]. CURRENT CARDIOLOGY REPORTS, 2016, 18 (06)
  • [40] Current and future clinical strategies in colon cancer prevention and the emerging role of chemoprevention
    Boursi, Ben
    Arber, Nadir
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (22) : 2274 - 2282
12345