Structure engineering of lanthanide functionalized metal-organic frameworks: A versatile tool for the early diagnosis of pheochromocytomas and paragangliomas

被引:9
作者
Song, Lijun [1 ]
Cui, Ruixue [1 ]
Tian, Fuli [2 ]
Liu, Zhiliang [1 ]
机构
[1] Inner Mongolia Univ, Sch Chem & Chem Engn, Inner Mongolia Key Lab Chem & Phys Rare Earth Mat, Hohhot 010021, Peoples R China
[2] Hainan Vocat Univ Sci & Technol, Key Lab Med & Edible Plants Resources Hainan Prov, Haikou 571126, Hainan, Peoples R China
关键词
Metal organic frameworks (MOFs); Fluorescence sensing; Paper-based sensor; 3-methoxytyramine; 3-METHOXYTYRAMINE; NEUROBLASTOMA; ENCAPSULATION; BIOMARKER; PROBE;
D O I
10.1016/j.saa.2021.120263
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
As a main extracellular metabolite of dopamine, 3-methoxytyramine (3-MT) is considered a potential biomarker of pheochromocytomas and paragangliomas. Therefore, the determination of 3-MT is of great significance in the early diagnosis of disease. However, it remains challenging for detecting 3-MT in consideration of sensitivity and accuracy. Here, a luminescent Eu3+ functionalized metal-organic frameworks (Eu3+@AI-MOF) with ultra-high chemical stability was constructed based on postsynthetic modification. Such a rational design greatly enhances the fluorescence signal of Eu3+@AI-MOF and it is endowed with excellent properties as a luminescent sensor to detect 3-MT in urine system. Intriguingly, the strong red emitting derived from antenna effect was significantly interdicted upon addition of 3-MT through the interaction between 3-MT and the ligand. The proposed sensing system exhibited many appealing analytical performances, such as excellent selectivity, high sensitivity and quick response. Remarkably, the developed paper-based sensor not only provides a portable and reliable strategy for direct detection of 3-MT but also expands the application of visual analysis tools. This work represents the first effort in designing a luminescent sensor to determine the metabolite biomarker 3-MT level and provides a new method for biomedical analysis. (C) 2021 Elsevier B.V. All rights reserved.
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页数:7
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