LncRNA as a diagnostic and prognostic biomarker in bladder cancer: a systematic review and meta-analysis

被引：115
作者：
Quan, Jing [1 ,2 ]
Pan, Xiang [1 ,2 ]
Zhao, Liwen [1 ,2 ]
Li, Zuwei [1 ]
Dai, Kangfu [2 ]
Yan, Fangli [2 ]
Liu, Suyue [2 ]
Ma, Hongfei [2 ]
Lai, Yongqing [1 ,2 ]
机构：
[1] Peking Univ, Shenzhen Hosp, Dept Urol, 1120 Lianhua Rd, Shenzhen 518036, Guangdong, Peoples R China
[2] Anhui Med Univ, Grad Sch, Hefei 230032, Anhui, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2018年 / 11卷
基金：
中国国家自然科学基金;
关键词：
lncRNA; bladder cancer; clinicopathological characteristics; prognosis; LONG NONCODING RNA; PREDICTS POOR-PROGNOSIS; PROMOTES TUMOR-GROWTH; MALIGNANT PHENOTYPES; INCREASED EXPRESSION; CELL-PROLIFERATION; SURVIVAL; METASTASIS; CARCINOMA; DOXORUBICIN;
D O I：
10.2147/OTT.S167853
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Bladder cancer is one of the most common urinary malignancies, and has a high recurrence rate and poor outcomes. In order to identify novel diagnostic and prognostic biomarkers for bladder cancer, we conducted a meta-analysis to analyze the association between long non-coding RNA (lncRNA) expression and survival in bladder cancer. Materials and methods: We searched literature from databases using our inclusion and exclusion criteria. STATA 14.0 software was used to analyze the data from collected studies and to construct the forest plots. A different effect size was selected for each meta-analysis. Results: After selection, 30 articles were found to be eligible. The present meta-analysis contains data from 13 articles about clinicopathological characteristics, six articles about diagnosis, and 16 articles about prognosis. In the present study, we found that many lncRNAs could function as potential diagnostic and prognostic markers in bladder cancer. Among these findings, UCA1 was expected to be a diagnostic biomarker for bladder cancer, while the aberrant expression of HOTAIR and GAS5 was associated with poor disease-free survival/recurrence-free survival/disease-specific survival. Conclusion: Overall, the present study is the first meta-analysis to assess the association between expression of lncRNAs and clinical value in patients with bladder cancer. LncRNAs hold promise as novel diagnostic and prognostic markers in bladder cancer.
引用
收藏
页码：6415 / 6424
页数：10
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