Moving Rehabilitation Research Forward: Developing Consensus Statements for Rehabilitation and Recovery Research

被引:38
作者
Bernhardt, Julie [1 ,2 ]
Borschmann, Karen [1 ,2 ]
Boyd, Lara [3 ,4 ]
Carmichael, S. Thomas [5 ,6 ]
Corbett, Dale [7 ,8 ]
Cramer, Steven C. [9 ,10 ,11 ]
Hoffmann, Tammy [12 ]
Kwakkel, Gert [13 ]
Savitz, Sean [14 ]
Saposnik, Gustavo [15 ]
Walker, Marion [16 ]
Ward, Nick [17 ,18 ]
机构
[1] NHMRC Ctr Res Excellence Stroke Rehabil & Recover, Parkville, Vic, Australia
[2] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia
[3] Univ British Columbia, Dept Phys Therapy, Vancouver, BC, Canada
[4] Univ British Columbia, Djavad Mowafaghian Ctr Brain Hlth, Vancouver, BC, Canada
[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA
[7] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada
[8] Univ Ottawa, Heart & Stroke Fdn Canadian Partnership Stroke Re, Ottawa, ON, Canada
[9] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA
[10] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92717 USA
[11] Univ Calif Irvine, Dept Phys Med & Rehabil, Irvine, CA USA
[12] Bond Univ, Ctr Res Evidence Based Practice, Gold Coast, Qld, Australia
[13] Vrije Univ Amsterdam, Med Ctr, Dept Rehabil Med, Neurosci Campus Amsterdam, Amsterdam, Netherlands
[14] UT Hlth, McGovern Med Sch, Stroke Program, Houston, TX USA
[15] Univ Toronto, Dept Med, Toronto, ON, Canada
[16] Univ Nottingham, Div Rehabil & Ageing, Nottingham, England
[17] UCL Inst Neurol, Sobell Dept Motor Neurosci, Queen Sq, London, England
[18] Natl Hosp Neurol & Neurosurg, Queen Sq, London, England
关键词
Consensus; neurobiology; recovery; rehabilitation; recommendations; stroke; UPPER-LIMB RECOVERY; CHRONIC STROKE; CLINICAL-TRIALS; STANDARDIZED APPROACH; BRAIN; PLASTICITY; BIOMARKERS; THERAPY; INTERVENTIONS; CONNECTIVITY;
D O I
10.1177/1545968317724290
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardized terminology is absent in both animal and human research, methods are poorly described, recovery biomarkers are not well defined, and we lack consistent timeframes or measures to examine outcomes. Agreed methods and conventions for developing, monitoring, evaluating and reporting interventions directed at improving recovery are lacking, and current approaches are often not underpinned by biology. We urgently need to better understand the biology of recovery and its time course in both animals and humans to translate evidence from basic science into clinical trials. A new international partnership of stroke recovery and rehabilitation experts has committed to advancing the research agenda. In May 2016, the first Stroke Recovery and Rehabilitation Roundtable will be held, with the aim of achieving an agreed approach to the development, conduct and reporting of research. A range of methods will be used to achieve consensus in four priority areas: pre-clinical recovery research; biomarkers of recovery; intervention development, monitoring and reporting; and measurement in clinical trials. We hope to foster a global network of researchers committed to advancing this exciting field. Recovery from stroke is challenging for many survivors. They deserve effective treatments underpinned by our evolving understanding of brain recovery and human behaviour. Working together, we can develop game-changing interventions to improve recovery and quality of life in those living with stroke.
引用
收藏
页码:694 / 698
页数:5
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