Genetic Predisposition for Osteoporosis and Fractures in Postmenopausal Women

被引：14
作者：
Mitek, Tomasz [1 ]
Nagraba, Lukasz [1 ]
Deszczynski, Jaroslaw [1 ]
Stolarczyk, Magda [1 ]
Kuchar, Ernest [2 ]
Stolarczyk, Artur [3 ]
机构：
[1] Warsaw Med Univ, Dept Orthoped & Rehabil, Warsaw, Poland
[2] Warsaw Med Univ, Clin Assessment Unit, Dept Pediat, Warsaw, Poland
[3] Warsaw Med Univ, Dept Clin Rehabil, Warsaw, Poland
来源：
ADVANCEMENTS AND INNOVATIONS IN HEALTH SCIENCES | 2019年 / 1211卷
关键词：
Fracture risk; Gene mapping; Gene polymorphism; Genetic predisposition; Osteoporosis; Postmenopausal women; WNT16; gene; ESTROGEN-RECEPTOR-ALPHA; BONE-MINERAL DENSITY; POLYMORPHISMS; MASS; ASSOCIATION; BETA; METAANALYSIS; PROTEIN-5; WNT16; LRP5;
D O I：
10.1007/5584_2019_413
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Osteoporosis is a disease with complex etiology where the genetic factors may account for as much as 50-85% of the risk of its development in postmenopausal women. The polymorphism of estrogen receptor genes (ESR1, ESR2) seems essential among the genetic factors. The goal of this study was to analyze polymorphisms of selected genes in a population of postmenopausal women treated for osteoporosis and to evaluate the influence of genetic and nongenetic factors on the estimated 10-year risk of fracture. The study group consisted of 214 women hospitalized for treatment of postmenopausal osteoporosis. We investigated the presence of ESR1, ESR2, LRP5, and WNT16 genetic polymorphisms and the risk of fracture in each woman. The main finding was that of significant differences in the polymorphisms of the WNT16 rs2908004 genetic variant, notably, the less frequent presence of TC allele in women with a greater risk of osteoporotic fractures. We conclude that the polymorphism of the WNT16 gene seems highly relevant in the pathogenesis of osteoporosis, which makes it a promising object for further research on the genetic background of fracture risk.
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页码：17 / 24
页数：8
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