Effect of Nigella sativa oil extracts on inflammatory and oxidative stress markers in Behcet's disease: A randomized, double-blind, placebo-controlled clinical trial

被引:0
|
作者
Amizadeh, Shahrzad [1 ]
Rashtchizadeh, Nadereh [1 ]
Khabbazi, Alireza [1 ]
Ghorbanihaghjo, Amir [2 ]
Ebrahimi, Ali-Asghar [1 ]
Vatankhah, Amir-Mansour [3 ]
Mahdavi, Aida Malek [1 ]
Taghizadeh, Mohsen [4 ,5 ]
机构
[1] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[4] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran
[5] Barij Essence Med Plants Res Ctr, Kashan, Iran
关键词
Nigella sativa; Behcet's disease; IL-10; TNF-alpha; Oxidative stress; RHEUMATOID-ARTHRITIS; CYTOKINE RESPONSE; THYMOQUINONE; PLASMA; LEUKOCYTES; SYNTHASE;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Objective: Behcet's disease (BD) is a chronic inflammatory disorder characterized by recurrent oral and genital aphthous ulcers, uveitis and skin lesions. Oxidative stress and inflammation have important role in the pathogenesis of BD. The aim of this study was to assess the effect of Nigella sativa (NS) oil administration on malondialdehyde (MDA), total anti-oxidant capacity (TAC), tumor necrosis factor-alpha (TNF-alpha), IL-10 and high sensitivity C-reactive protein (hs- CRP) levels in patients with BD. Materials and Methods: In this randomized, double-blind and placebo-controlled clinical trial, 96 BD patients were randomly assigned to NS or placebo groups. Study groups received 1000 mg/day NS oil and placebo soft gels for 8 weeks. Serum levels of TNF-alpha, IL-10, hs-CRP, MDA and TAC were measured before and after treatment. Results: Eighty-nine individuals completed the study. Significant decreases in the serum levels of MDA and increases in the serum levels of TAC were found in the NS group. However, differences in the changes of MDA and TAC in the NS and placebo groups were not significant. Pre- and post-intervention changes of TNF-alpha, IL-10 and hs-CRP levels in the NS group were non-significant. Conclusion: NS 1000 mg per day is probably not effective in reducing the inflammatory and oxidative markers in BD.
引用
收藏
页码:181 / 189
页数:9
相关论文
共 50 条
  • [21] Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double-blind, placebo-controlled, clinical trial
    Moyaghati, Mohammad Reza Ardakani
    Yousefi, Mahdi
    Saghebi, Seyed Ahmad
    Vazin, Mahmoud Sadeghi
    Iraji, Aida
    Mosavat, Seyed Hamdollah
    PHYTOTHERAPY RESEARCH, 2019, 33 (05) : 1404 - 1412
  • [22] Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial
    Rafati, Mohammadreza
    Ghasemi, Arash
    Saeedi, Majid
    Habibi, Emran
    Salehifar, Ebrahim
    Mosazadeh, Mahmood
    Maham, Monireh
    COMPLEMENTARY THERAPIES IN MEDICINE, 2019, 47
  • [23] Ineffectiveness of allopurinol in reduction of oxidative stress in diabetic patients; a randomized, double-blind placebo-controlled clinical trial
    Afshari, M
    Larijani, B
    Rezaie, A
    Mojtahedi, A
    Zamani, MJ
    Astanehi-Asghari, F
    Mostafalou, S
    Hossein-nezhad, A
    Heshmat, R
    Abdollahi, M
    BIOMEDICINE & PHARMACOTHERAPY, 2004, 58 (10) : 546 - 550
  • [24] Colchicine versus placebo in Behcet's disease: randomized, double-blind, controlled crossover trial
    Davatchi, Fereydoun
    Abdollahi, Bahar Sadeghi
    Banihashemi, Arash Tehrani
    Shahram, Farhad
    Nadji, Abdolhadi
    Shams, Hormoz
    Chams-Davatchi, Cheyda
    MODERN RHEUMATOLOGY, 2009, 19 (05) : 542 - 549
  • [25] The effects of inulin supplementation on clinical indices, oxidative stress and inflammatory biomarkers in women with migraine: A double-blind, placebo-controlled, randomized trial
    Vajdi, Mahdi
    Khorvash, Fariborz
    Askari, Gholamreza
    JOURNAL OF FUNCTIONAL FOODS, 2024, 121
  • [26] Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial
    Zahedi, Hoda
    Hosseinzadeh-Attar, Mohammad Javad
    Shadnoush, Mahdi
    Sahebkar, Amirhossein
    Barkhidarian, Bahareh
    Sadeghi, Omid
    Najafi, Atabak
    Hosseini, Saeed
    Qorbani, Mostafa
    Ahmadi, Arezoo
    Ardehali, Seyed Hossein
    Norouzy, Abdolreza
    PHYTOTHERAPY RESEARCH, 2021, 35 (08) : 4605 - 4615
  • [27] The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial
    Nouri, Mehran
    Amani, Reza
    Nasr-Esfahani, Mohammadhossein
    Tarrahi, Mohammad Javad
    PHYTOTHERAPY RESEARCH, 2019, 33 (12) : 3203 - 3211
  • [28] Effects of N-acetylcysteine supplementation on disease activity, oxidative stress, and inflammatory and metabolic parameters in rheumatoid arthritis patients: a randomized double-blind placebo-controlled trial
    Esalatmanesh, Kamal
    Jamali, Alireza
    Esalatmanesh, Roozbeh
    Soleimani, Zahra
    Khabbazi, Alireza
    Mahdavi, Aida Malek
    AMINO ACIDS, 2022, 54 (03) : 433 - 440
  • [29] Effects of Probiotics on Biomarkers of Oxidative Stress and Inflammatory Factors in Petrochemical Workers: A Randomized, Double-blind, Placebo-controlled Trial
    Mohammadi, Ali Akbar
    Jazayeri, Shima
    Khosravi-Darani, Kianoush
    Solati, Zahra
    Mohammadpour, Nakisa
    Asemi, Zatollah
    Adab, Zohre
    Djalali, Mahmoud
    Tehrani-Doost, Mehdi
    Hosseini, Mostafa
    Eghtesadi, Shahryar
    INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 2015, 6
  • [30] Effects of melatonin supplementation on disease activity, oxidative stress, inflammatory, and metabolic parameters in patients with rheumatoid arthritis: a randomized double-blind placebo-controlled trial
    Esalatmanesh, Kamal
    Loghman, Amirhossein
    Esalatmanesh, Roozbeh
    Soleimani, Zahra
    Khabbazi, Alireza
    Mahdavi, Aida Malek
    Mousavi, Seyed Gholam Abbas
    CLINICAL RHEUMATOLOGY, 2021, 40 (09) : 3591 - 3597