Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells:: A new type of potent squalene epoxidase inhibitors

被引：11
作者：
Gotteland, JP
Loubat, C
Planty, B
Junquéro, D
Delhon, A
Halazy, S
机构：
[1] Ctr Rech Pierre Fabre, Div Med Chem, F-81106 Castres, France
[2] Ctr Rech Pierre Fabre, Div Cardiovasc Dis, F-81106 Castres, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(98)00213-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG(2) cells as cholesterol biosynthesis inhibitors. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1337 / 1342
页数：6
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