Probiotics, prebiotics and colorectal cancer prevention

被引：171

作者：

Ambalam, Padma ^{[1
]}

Raman, Maya ^{[2
]}

Purama, Ravi Kiran ^{[3
]}

Doble, Mukesh ^{[2
]}

机构：

[1] Christ Coll, Dept Biotechnol, Rajkot, Gujarat, India

[2] Indian Inst Technol, Bioengn & Drug Design Lab, Dept Biotechnol, Bhupat & Jyoti Mehta Sch Biosci & Bioengn, Madras 600036, Tamil Nadu, India

[3] NIT Calicut, Sch Biotechnol, Chem Bldg,East Campus, Calicut, Kerala, India

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2016年 / 30卷 / 01期

关键词：

Colorectal cancer; Gut microbiota; Probiotics; Prebiotics; Synbiotics; Lactobacillus; Bifidobacteria; POSTOPERATIVE INFECTIOUS COMPLICATIONS; LACTOBACILLUS-RHAMNOSUS GG; ABERRANT CRYPT FOCI; A-ALPHA-C; FUSOBACTERIUM-NUCLEATUM; DOUBLE-BLIND; RESISTANT STARCH; COLON-CANCER; BIFIDOBACTERIUM-LACTIS; GUT MICROBIOTA;

D O I：

10.1016/j.bpg.2016.02.009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Colorectal cancer (CRC), the third major cause of mortality among various cancer types in United States, has been increasing in developing countries due to varying diet and dietary habits and occupational hazards. Recent evidences showed that composition of gut microbiota could be associated with the development of CRC and other gut dysbiosis. Modulation of gut microbiota by probiotics and prebiotics, either alone or in combination could positively influence the cross-talk between immune system and microbiota, would be beneficial in preventing inflammation and CRC. In this review, role of probiotics and prebiotics in the prevention of CRC has been discussed. Various epidemiological and experimental studies, specifically gut microbiome research has effectively improved the understanding about the role of probiotics and microbial treatment as anticarcinogenic agents. A few human studies support the beneficial effect of probiotics and prebiotics; hence, comprehensive understanding is urgent to realize the clinical applications of probiotics and prebiotics in CRC prevention. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：119 / 131

页数：13

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