Escitalopram (10-20 mg/day) is effective and well tolerated in a placebo-controlled study in depression in primary care

被引:200
作者
Lepola, UM
Loft, H
Reines, EH
机构
[1] H Lundbeck & Co AS, Int Clin Res, DK-2500 Copenhagen, Denmark
[2] Univ Oulu, Dept Psychiat, Oulu, Finland
[3] Univ Helsinki, Helsinki, Finland
[4] Kuop Psykiatripalvelu OY Psychiat Res, Clin Kuopio, Kuopio, Finland
关键词
antidepressant; citalopram; efficacy; enantiomer; escitalopram; flexible dose; MADRS; major depressive disorder; SSRI;
D O I
10.1097/00004850-200307000-00003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Escitalopram was compared to placebo in moderately to severely depressed patients in primary care with citalopram as the active reference. Patients were randomized to receive flexible doses of 10-20 mg/day escitalopram (n = 155), 20-40 mg/day citalopram (n = 160), or placebo (n = 154) over an 8-week double-blind period. The primary efficacy parameter was the change from baseline to last assessment in the Montgomery-Asberg Depression Rating Scale total score. Escitalopram produced a statistically significant therapeutic difference of 2.9 points (P = 0.002) compared to placebo, and escitalopram was consistently and statistically significantly more efficacious than placebo from week 1 onwards. Analysis of Clinical Global Impression-Severity and Clinical Global Impression-improvement confirmed the primary efficacy results. By week 8, significantly more patients had responded to treatment with escitalopram than with citalopram (P = 0.021) or placebo (P = 0.009). Escitalopram was as well tolerated as citalopram and had a similar adverse event profile. Both escitalopram- and citalopram-treated patients had placebo-level adverse event withdrawal rates (3% and 4%, respectively). This study demonstrates the consistent antidepressant efficacy and excellent tolerability of escitalopram 10-20 mg/day in primary care patients with major depressive disorder. Int Clin Psychopharmacol 18:211-217 (C) 2003 Lippincott Williams Wilkins.
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页码:211 / 217
页数:7
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