The therapeutic effect of FTY720 on lupus nephritis in autoimmune MRL/lpr mice

被引：0

作者：

Sugahara, K ^{[1
]}

Kataoka, H ^{[1
]}

Ohtsuki, M ^{[1
]}

Hoshino, Y ^{[1
]}

Chiba, K ^{[1
]}

机构：

[1] Mitsubishi Pharma Corp, Res Lab 3, Pharmaceut Res Unit, Div Res & Dev, Yokohama, Kanagawa, Japan

来源：

IMMUNOLOGY 2004: AUTOIMMUNITY, GENETIC AND DEGENERATIVE DISORDERS, MALIGNANCIES, AND TRANSPLANTATION | 2004年

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sphingosine 1-phosphate receptor agonist, FTY720 at oral doses of 0.03 to 1 mg/kg exhibited the prophylactic and therapeutic effect on lupus nephritis spontaneously developed in MRL/lpr mice. The therapeutical administration of FTY720 resulted in a decrease in the number of T cells, especially CD4(+) T cells, infiltrated into kidney as well as reduction of lymphocytes in blood. Moreover, the elevation of Th1 cytokine/chemokine mRNA expression was decreased in kidneys of FTY720-treated group. These results suggest that FTY720 decreases autoreactive Th1 cell infiltration into kidneys by reduction of circulating lymphocytes in blood, and thereby shows a marked therapeutic effect on progressing lupus nephritis of MRL/lpr mice.

引用

页码：271 / 274

页数：4