Shape-specific polymeric nanomedicine: emerging opportunities and challenges

被引:130
作者
Tao, Li [2 ]
Hu, Walter [2 ]
Liu, Yaling [3 ]
Huang, Gang [1 ]
Sumer, Baran D. [4 ]
Gao, Jinming [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Harold C Simmons Comprehens Canc Ctr, Dept Pharmacol, Dallas, TX 75390 USA
[2] Univ Texas Dallas, Erik Johnsson Sch Engn & Comp Sci, Richardson, TX 75080 USA
[3] Lehigh Univ, Dept Mech Engn & Mech, Bethlehem, PA 18015 USA
[4] Univ Texas SW Med Ctr Dallas, Dept Otolaryngol, Dallas, TX 75390 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
shape-specific nanomedicine; non-spherical nanoparticles; top-down engineering method; drug delivery; intravascular dynamics; cell targeting; RECEPTOR-MEDIATED ENDOCYTOSIS; ENGINEERED DRUG THERAPIES; MICROFABRICATED PARTICLES; CELLULAR INTERNALIZATION; SOFT LITHOGRAPHY; DELIVERY SYSTEMS; FABRICATION; NANOPARTICLES; FLOW; SIZE;
D O I
10.1258/ebm.2010.010243
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Size and shape are fundamental properties of micro/nanoparticles that are critically important for nanomedicine applications. Extensive studies have revealed the effect of particle size on spherical particles with respect to circulation, extravasation and distribution in vivo. In contrast, the importance of particle shape has only recently begun to emerge. For example, cylindrically-shaped filomicelles (diameter 22-60 nm, length 8-18 mu m) have shown persistent blood circulation for up to one week after intravenous injection, much longer than their spherical counterparts. Disc-shaped nanoparticles have demonstrated higher in vivo targeting specificity to endothelial cells expressing intercellular adhesion molecule receptors in mice than spherical particles of similar size. In this Minireview, we will discuss the recent advances in the fabrication of shape-specific nanoparticles and their unique biological and pharmacological properties. Computational models are presented to provide mechanistic understanding of the shape effects on cell targeting under flow conditions. Shape-specific nanoparticles have the potential to significantly improve the performance of nanomedicine in diagnostic imaging and targeted drug delivery applications.
引用
收藏
页码:20 / 29
页数:10
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