Innate mechanisms of viral recognition

被引：8

作者：

Drutskaya, M. S. ^{[1
]}

Belousov, P. V. ^{[2
,3
]}

Nedospasov, S. A. ^{[1
,2
,3
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

[3] Moscow MV Lomonosov State Univ, Dept Biol, Moscow 119991, Russia

来源：

MOLECULAR BIOLOGY | 2011年 / 45卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

innate immunity; pathogen recognition receptors; toll-like receptors; RIG-1-like receptors; anti-viral response; HEPATITIS-C VIRUS; DOUBLE-STRANDED-RNA; STRUCTURAL-FUNCTIONAL ORGANIZATION; HUMAN CYTOMEGALOVIRUS UL141; TOLL-LIKE RECEPTORS; IFN-BETA PROMOTER; INDUCIBLE GENE-I; CD8(+) T-CELLS; NF-KAPPA-B; RIG-I;

D O I：

10.1134/S0026893311010043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viruses are obligate parasites which can infect cells of all living organisms. Multiple antiviral defense mechanisms appeared early in the evolution of the immune system. Higher vertebrates possess the most complex antiviral immunity based on both innate and adoptive immune responses. However, a majority of living organisms, including plants and invertebrates, rely exclusively on innate immune mechanisms for protection against viral infections. There are some striking similarities in several components of innate immune recognition in mammals, plants, and insects suggesting that these signaling cascades are highly conserved in the evolution of the immune system. This review summarizes recent advances in the field of innate immune recognition of viruses, with a focus on pattern-recognition receptors.

引用

页码：5 / 15

页数：11

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