Analysis of benzodiazepines by thin-layer chromatography and tandem mass spectrometry

被引:0
作者
Tames, F
Watson, ID
Morden, WE
Wilson, ID
机构
[1] AstraZeneca Pharmaceut, Dept Drug Metab & Pharmacokinet, Macclesfield SK10 4TG, Cheshire, England
[2] Univ Hosp, Dept Clin Biochem, Liverpool L9 7AL, Merseyside, England
[3] LGC, Runcorn WA7 4QD, Cheshire, England
关键词
TLC; mass spectrometry; tandem mass spectrometry; urine; drugs of abuse; confirmation of identity;
D O I
暂无
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Tandem mass spectrometry has been applied to the analysis and identification of several common benzodiazepines after high-performance thin-layer chromatography on silica gel. FAB-MS and MS-MS, directly from the silica matrix, without prior extraction, were successfully used both for standards and for urine extracts. The potential for confirming the identity of abused drugs detected in initial TLC screening procedures by subsequent use of MS-MS is discussed.
引用
收藏
页码:432 / 436
页数:5
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