Caspase activation

被引：67
作者：
Boatright, KM
Salvesen, GS
机构：
[1] Burnham Inst, Program Apoptosis & Cell Death, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, Dept Mol Pathol, La Jolla, CA 92037 USA
来源：
PROTEASES AND THE REGULATION OF BIOLOGICAL PROCESSES | 2003年 / 70卷
关键词：
D O I：
10.1042/bss0700233
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Caspase activation is the 'point of no return' commitment to cell death. Synthesized as inactive zymogens, it is essential that the caspases remain inactive until the death signal is received. It is known for the downstream executioner caspases-3 and -7 that the activation event is proteolytic cleavage, and this had been assumed to apply to the initiator caspases as well. However, recent studies conducted on caspases-2, -8 and -9 have challenged this tenet of caspase activation. In this review we focus on the molecular details of caspase activation, with emphasis on recent work that provides a pleasing explanation for the differential requirements for the activation of executioner and initiator caspases.
引用
收藏
页码：233 / 242
页数：10
相关论文
共 40 条
  • [1] Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    Acehan, D
    Jiang, XJ
    Morgan, DG
    Heuser, JE
    Wang, XD
    Akey, CW
    [J]. MOLECULAR CELL, 2002, 9 (02) : 423 - 432
  • [2] AINEMRI ES, 1996, CELL, V87, P171
  • [3] A unified model for apical caspase activation
    Boatright, KM
    Renatus, M
    Scott, FL
    Sperandio, S
    Shin, H
    Pedersen, IM
    Ricci, JE
    Edris, WA
    Sutherlin, DP
    Green, DR
    Salvesen, GS
    [J]. MOLECULAR CELL, 2003, 11 (02) : 529 - 541
  • [4] Dimeric procaspase-3 unfolds via a four-state equilibrium process
    Bose, K
    Clark, AC
    [J]. BIOCHEMISTRY, 2001, 40 (47) : 14236 - 14242
  • [5] Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding
    Chai, JJ
    Wu, Q
    Shiozaki, E
    Srinivasula, SM
    Alnemri, ES
    Shi, YG
    [J]. CELL, 2001, 107 (03) : 399 - 407
  • [6] c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
    Chang, DW
    Xing, Z
    Pan, Y
    Algeciras-Schimnich, A
    Barnhart, BC
    Yaish-Ohad, S
    Peter, ME
    Yang, XL
    [J]. EMBO JOURNAL, 2002, 21 (14) : 3704 - 3714
  • [7] Insights into the regulatory mechanism for caspase-8 activation
    Donepudi, M
    Mac Sweeney, A
    Briand, C
    Grütter, MG
    [J]. MOLECULAR CELL, 2003, 11 (02) : 543 - 549
  • [8] Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold
    Eichinger, A
    Beisel, HG
    Jacob, U
    Huber, R
    Medrano, FJ
    Banbula, A
    Potempa, J
    Travis, J
    Bode, W
    [J]. EMBO JOURNAL, 1999, 18 (20) : 5453 - 5462
  • [9] Structural biology - Controlling the caspases
    Fesik, SW
    Shi, YG
    [J]. SCIENCE, 2001, 294 (5546) : 1477 - 1478
  • [10] Mitochondria and apoptosis
    Green, DR
    Reed, JC
    [J]. SCIENCE, 1998, 281 (5381) : 1309 - 1312
1234