Chronic Constipation

被引:12
作者
Brenner, Darren M. [1 ]
Shah, Marmy [2 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Div Gastroenterol, 675 North St Clair Ave,Suite 17-250, Chicago, IL 60611 USA
[2] Loyola Univ, Med Ctr, Div Gastroenterol & Nutr, 2160 South First Ave,Bldg 54-Room 167, Maywood, IL 60153 USA
关键词
Constipation; Pathophysiology; Motility; Diagnostic testing; Anorectal manometry; Laxatives; Secretagogues; PLACEBO-CONTROLLED TRIAL; IDIOPATHIC CONSTIPATION; POLYETHYLENE-GLYCOL; CLINICAL UTILITY; COLONIC MOTILITY; ADULTS; ERYTHROMYCIN; MANAGEMENT; LUBIPROSTONE; MULTICENTER;
D O I
10.1016/j.gtc.2016.02.013
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Chronic constipation is a common disorder that affects approximately 20% of the population and significantly impacts an individual's quality of life. The diagnosis can be made using standard criteria, and in the absence of alarm signs or symptoms, a determination of the underlying etiology/etiologies should be undertaken. In many instances, these will be gleaned from the history and physical examination. Specialized diagnostic testing may be warranted after the failure of initial laxative trials. Many therapeutic classes of laxatives exist with recent analyses indicating that practicing physicians prefer to use over-the-counter therapies in lieu of more strongly evidence-based prescription pharmaceuticals.
引用
收藏
页码:205 / +
页数:13
相关论文
共 31 条
[1]  
Agency for Healthcare Research and Quality (AHRQ), WIR MOT CAPS VERS OT
[2]   Efficacy and Safety of Lubiprostone in Patients with Chronic Constipation [J].
Barish, Charles F. ;
Drossman, Douglas ;
Johanson, John F. ;
Ueno, Ryuji .
DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (04) :1090-1097
[3]  
Bassotti G, 1998, Z GASTROENTEROL, V36, P209
[4]   Systematic review: impact of constipation on quality of life in adults and children [J].
Belsey, J. ;
Greenfield, S. ;
Candy, D. ;
Geraint, M. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2010, 31 (09) :938-949
[5]   Systematic review and meta analysis: polyethylene glycol in adults with non-organic constipation [J].
Belsey, J. D. ;
Geraint, M. ;
Dixon, T. A. .
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2010, 64 (07) :944-955
[6]   American Gastroenterological Association Technical Review on Constipation [J].
Bharucha, Adil E. ;
Pemberton, John H. ;
Locke, G. Richard, III .
GASTROENTEROLOGY, 2013, 144 (01) :218-238
[7]  
Brenner D.M., 2014, Am. J. Gastroenterol. Suppl, V2, P38, DOI [10.1038/ajgsup.2014.8, DOI 10.1038/AJGSUP.2014.8]
[8]  
Brenner DM, 2006, GASTROENTEROL REP, V1, P4
[9]   A randomized, multicenter, placebo-controlled trial of polyethylene glycol laxative for chronic treatment of chronic constipation [J].
DiPalma, Jack A. ;
Cleveland, Mark V. B. ;
McGowan, John ;
Herrera, Jorge L. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (07) :1436-1441
[10]   Effect of intravenous erythromycin on the colonic motility of children and young adults during colonic manometry [J].
Dranove, Jason ;
Horn, Debra ;
Reddy, S. Narasimha ;
Croffie, Joseph .
JOURNAL OF PEDIATRIC SURGERY, 2010, 45 (04) :777-783