Epirubicin: Biological Properties, Analytical Methods, and Drug Delivery Nanosystems

被引：16

作者：

Luiz, Marcela Tavares ^{[1
]}

Dutra, Jessyca Aparecida Paes ^{[2
]}

Di Filippo, Leonardo Delello ^{[2
]}

Junior, Alberto Gomes Tavares ^{[2
]}

Tofani, Larissa Bueno ^{[1
]}

Marchetti, Juliana Maldonado ^{[1
]}

Chorilli, Marlus ^{[2
]}

机构：

[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, Brazil

[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil

来源：

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY | 2021年 / 53卷 / 05期

关键词：

Chromatography; fluorimetry; nanomedicine; nanoparticles; spectroscopy; SOLID LIPID NANOPARTICLES; IN-VITRO; HUMAN PLASMA; POLY(BUTYL CYANOACRYLATE); CHROMATOGRAPHY METHOD; ANTINEOPLASTIC DRUGS; FACTOR ANTIBODY; PHARMACOKINETICS; CHEMOTHERAPY; METABOLITE;

D O I：

10.1080/10408347.2021.2007469

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Epirubicin (EPI) is a chemotherapeutic agent belonging to the anthracycline drug class indicated for treating several tumors. It acts by suppressing the DNA and RNA synthesis by intercalating between their base pair. However, several side effects are associated with this therapy, including cardiotoxicity and myelosuppression. Therefore, EPI delivery in nanosystems has been an interesting strategy to overcome these limitations and improve the safety and efficacy of EPI. Thus, analytical methods have been used to understand and characterize these nanosystems, including spectrophotometric, spectrofluorimetric, and chromatography. Spectrophotometric and spectrofluorimetric methods have been used to quantify EPI in less complex matrices due to their efficiency, low cost, and green chemistry character. By contrast, high-performance liquid chromatography is a suitable method for detecting EPI in more complex matrices (e.g., plasm and urine) owing to its high sensitivity. This review summarizes physicochemical and pharmacokinetic properties of EPI, its application in drug delivery nanosystems, and the analytical methods employed in its quantification in different matrices, including blood, plasm, urine, and drug delivery nanosystems.

引用

页码：1080 / 1093

页数：14

共 96 条

[11] Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy [J].

Bayat, Parvaneh ;

Pakravan, Parvaneh ;

Salouti, Mojtaba ;

Dolatabadi, Jafar Ezzati Nazhad .

ADVANCED PHARMACEUTICAL BULLETIN, 2021, 11 (01) :96-103

[12] Stability of a highly concentrated solution of epirubicin for conventional transcatheter arterial chemoembolization [J].

Bennis, Youssef ;

Savry, Amandine ;

Correard, Florian ;

Montana, Marc ;

Sauzet, Christophe ;

Gauthier-Villano, Laurence ;

Pisano, Pascale ;

Pourroy, Bertrand .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 495 (02) :956-962

[13] An ion-pairing, reversed-phase liquid chromatography method to assess the cross-contamination of cancer chemotherapy infusions prepared in a dual-operator aseptic isolator [J].

Brachet, G. ;

Bruno, C. ;

Boulay, D. ;

Tournamille, J. F. ;

Gyan, E. ;

Viaud-Massuard, M. C. ;

Respaud, R. .

DRUG TESTING AND ANALYSIS, 2016, 8 (09) :985-990

[14] Cyclophosphamide, Epirubicin, and Fluorouracil Versus Dose-Dense Epirubicin and Cyclophosphamide Followed by Paclitaxel Versus Doxorubicin and Cyclophosphamide Followed by Paclitaxel in Node-Positive or High-Risk Node-Negative Breast Cancer [J].

Burnell, Margot ;

Levine, Mark N. ;

Chapman, Judith-Anne W. ;

Bramwell, Vivien ;

Gelmon, Karen ;

Walley, Barbara ;

Vandenberg, Ted ;

Chalchal, Haji ;

Albain, Kathy S. ;

Perez, Edith A. ;

Rugo, Hope ;

Pritchard, Kathleen ;

O'Brien, Patti ;

Shepherd, Lois E. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (01) :77-82

[15] Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin [J].

Chen, Hongli ;

Xie, Li Qin ;

Qin, Jingwen ;

Jia, Yajing ;

Cai, Xinhua ;

Nan, WenBin ;

Yang, Wancai ;

Lv, Feng ;

Zhang, Qi Qing .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 138 :1-9

[16] Epirubicin-loaded marine carrageenan oligosaccharide capped gold nanoparticle system for pH-triggered anticancer drug release [J].

Chen, Xiangyan ;

Han, Wenwei ;

Zhao, Xia ;

Tang, Wei ;

Wang, Fahe .

SCIENTIFIC REPORTS, 2019, 9 (1)

[17]

Conte P F, 2000, Clin Breast Cancer, V1 Suppl 1, pS46, DOI 10.3816/CBC.2000.s.009

[18] Chemotaxis-based smart drug delivery of epirubicin using a 3D printed microfluidic chip [J].

Dalvand, Kolsoum ;

Ghiasvand, A. ;

Gupta, Vipul ;

Paull, Brett .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 1162

[19] Advanced drug delivery nanosystems (aDDnSs): a mini-review [J].

Demetzos, Costas ;

Pippa, Natassa .

DRUG DELIVERY, 2014, 21 (04) :250-257

[20] The use of infrared spectroscopic techniques to characterize nanomaterials and nanostructures: A review [J].

Dendisova, Marcela ;

Jenistova, Adela ;

Parchanska-Kokaislova, Alzbeta ;

Matejka, Pavel ;

Prokopec, Vadym ;

Svecova, Marie .

ANALYTICA CHIMICA ACTA, 2018, 1031 :1-14

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