Nonalcoholic fatty liver disease in a severely obese adolescent. An arguable liver biopsy

被引：4

作者：

Bertrand, J. -B. ^{[1
,2
]}

Lefevre, H. ^{[1
]}

Prevot, S. ^{[3
,4
]}

Perlemuter, G. ^{[4
,5
,6
]}

机构：

[1] Grp Hosp Cochin St Vincent de Paul, Hop Cochin, AP HP, Serv Med Adolescents Pr Moro, F-75679 Paris 14, France

[2] Univ Paris 05, Fac Med Paris Descartes, F-75270 Paris 06, France

[3] Hop Antoine Beclere, AP HP, Serv Anat Pathol, F-92140 Clamart, France

[4] Univ Paris Sud, Fac Med Paris Sud, F-94270 Le Kremlin Bicetre, France

[5] Hop Antoine Beclere, AP HP, Serv Hepatogastroenterol, F-92140 Clamart, France

[6] IPSIT, U996, INSERM, F-92140 Clamart, France

来源：

ARCHIVES DE PEDIATRIE | 2011年 / 18卷 / 01期

关键词：

INSULIN-RESISTANCE; METABOLIC SYNDROME; FIBROSIS; CHILDREN; PREVALENCE; ASSOCIATION;

D O I：

10.1016/j.arcped.2010.10.010

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The growing epidemic of juvenile obesity has prompted pediatricians to investigate obesity-related conditions in obese teenagers. We report a clinical case of severe hepatic fibrosis in an adolescent with severe and recent obesity. Because of elevated serum aminotransferase levels, abnormal hepatic ultrasonography and insulin resistance (impaired glucose tolerance), we suspected nonalcoholic steatohepatitis (NASH). Disease activity and fibrosis were confirmed on liver biopsy. Considering the risk of progression toward cirrhosis and its complications, and the pathological liver lesions, we started long-term medical monitoring and drug therapy to control weight loss. At present, although biopsy is the only validated way to establish the diagnosis of NASH, there is no consensus on its indication when NASH is suspected. Noninvasive strategies are attractive but require validation in children. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：62 / 65

页数：4

共 19 条

[11] Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease [J].