Lessons from a rare disease: IgG subclass and disease severity in alloimmune antenatal membranous nephropathy

被引：6

作者：

Beck, Laurence H. ^{[1
]}

机构：

[1] Boston Univ, Med Ctr, Boston, MA USA

来源：

KIDNEY INTERNATIONAL | 2015年 / 87卷 / 03期

关键词：

NEUTRAL ENDOPEPTIDASE; GENE;

D O I：

10.1038/ki.2014.367

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Fetomaternal alloimmunization against neutral endopeptidase (NEP) is a rare cause of antenatal membranous nephropathy, yet lessons from such cases continue to elucidate important pathophysiologic points. Vivarelli and colleagues describe two recent cases of this disease and demonstrate that despite a common genetic cause, differences in maternal anti-NEP IgG subclass modulate disease severity through such mechanisms as complement activation and enzyme inhibition.

引用

页码：494 / 497

页数：4

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