Rapid two-step synthesis of mitrin from heparosan: A replacement for heparin

被引：24

作者：

Kuberan, B

Beeler, DL

Lawrence, R

Lech, M

Rosenberg, RD

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Mol Med, Boston, MA 02215 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 41期

关键词：

D O I：

10.1021/ja036737g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have engineered a two-step enzymatic synthesis of Mitrin which is a more potent and homogeneous anticoagulant than the current animal-derived heparin. This engineered heparin may have advantages of being free from animal-derived pathogens and may also have reduced side effects such as heparin induced thrombocytopenia. This approach can also be extended to tailor heparin-based drugs with improved therapeutic characteristics to treat other disorders or infections in which heparin-like molecules play a major role. Copyright © 2003 American Chemical Society.

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页码：12424 / 12425

页数：2

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