PfRH5 as a candidate vaccine for Plasmodium falciparum malaria

被引：17
作者：
Drew, Damien R. [1 ]
Beeson, James G. [1 ,2 ]
机构：
[1] Burnet Inst, Melbourne, Vic, Australia
[2] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia
来源：
TRENDS IN PARASITOLOGY | 2015年 / 31卷 / 03期
关键词：
PfRH5; Plasmodium falciparum; malaria; vaccines; invasion; ERYTHROCYTE INVASION; ANTIBODIES; BASIGIN;
D O I：
10.1016/j.pt.2015.02.001
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
PfRH5 has recently emerged as a strong vaccine candidate for Plasmodium falciparum malaria. Antibodies inhibit invasion of erythrocytes by merozoites and blood-stage replication, and PfRH5 is a significant target of acquired human immunity. Recent studies have shown protective efficacy of PfRH5 vaccines in a non-human primate model of malaria.
引用
收藏
页码：87 / 88
页数：2
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