Clinical potential of the Hippo-YAP pathway in bladder cancer

被引：5
|
作者：
Cheng, Xin [1 ,2 ,3 ]
Lou, Kecheng [1 ,2 ,3 ]
Ding, Liang [1 ,2 ,3 ]
Zou, Xiaofeng [2 ,3 ,4 ]
Huang, Ruohui [2 ,3 ,4 ]
Xu, Gang [2 ,3 ,4 ]
Zou, Junrong [2 ,3 ,4 ]
Zhang, Guoxi [2 ,3 ,4 ]
机构：
[1] Gannan Med Univ, Clin Coll 1, Ganzhou, Peoples R China
[2] Gannan Med Univ, Affiliated Hosp 1, Dept Urol, Ganzhou, Peoples R China
[3] Gannan Med Univ, Affiliated Hosp 1, Inst Urol, Ganzhou, Peoples R China
[4] Gannan Med Univ, Dept Jiangxi Engn Technol Res Ctr Calculi Prevent, Ganzhou, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
基金：
中国国家自然科学基金;
关键词：
bladder cancer; Hippo pathway; YAP; chemoresistant; cancer stem cell; MUTANT ALPHA-SUBUNIT; EPITHELIAL-MESENCHYMAL TRANSITION; AMPK-MEDIATED REGULATION; STEM-CELLS; TUMOR-SUPPRESSOR; OVARIAN-CANCER; SELF-RENEWAL; PHASE-II; NEOPLASTIC TRANSFORMATION; CONTACT INHIBITION;
D O I：
10.3389/fonc.2022.925278
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bladder cancer (BC) is one of the world's most frequent cancers. Surgery coupled with adjuvant platinum-based chemotherapy is the current standard of therapy for BC. However, a high proportion of patients progressed to chemotherapy-resistant or even neoplasm recurrence. Hence, identifying novel treatment targets is critical for clinical treatment. Current studies indicated that the Hippo-YAP pathway plays a crucial in regulating the survival of cancer stem cells (CSCs), which is related to the progression and reoccurrence of a variety of cancers. In this review, we summarize the evidence that Hippo-YAP mediates the occurrence, progression and chemotherapy resistance in BC, as well as the role of the Hippo-YAP pathway in regulating bladder cancer stem-like cells (BCSCs). Finally, the clinical potential of Hippo-YAP in the treatment of BC was prospected.
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收藏
页数：15
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