Clinical potential of the Hippo-YAP pathway in bladder cancer

被引：5

作者：

Cheng, Xin ^{[1
,2
,3
]}

Lou, Kecheng ^{[1
,2
,3
]}

Ding, Liang ^{[1
,2
,3
]}

Zou, Xiaofeng ^{[2
,3
,4
]}

Huang, Ruohui ^{[2
,3
,4
]}

Xu, Gang ^{[2
,3
,4
]}

Zou, Junrong ^{[2
,3
,4
]}

Zhang, Guoxi ^{[2
,3
,4
]}

机构：

[1] Gannan Med Univ, Clin Coll 1, Ganzhou, Peoples R China

[2] Gannan Med Univ, Affiliated Hosp 1, Dept Urol, Ganzhou, Peoples R China

[3] Gannan Med Univ, Affiliated Hosp 1, Inst Urol, Ganzhou, Peoples R China

[4] Gannan Med Univ, Dept Jiangxi Engn Technol Res Ctr Calculi Prevent, Ganzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

基金：

中国国家自然科学基金;

关键词：

bladder cancer; Hippo pathway; YAP; chemoresistant; cancer stem cell; MUTANT ALPHA-SUBUNIT; EPITHELIAL-MESENCHYMAL TRANSITION; AMPK-MEDIATED REGULATION; STEM-CELLS; TUMOR-SUPPRESSOR; OVARIAN-CANCER; SELF-RENEWAL; PHASE-II; NEOPLASTIC TRANSFORMATION; CONTACT INHIBITION;

D O I：

10.3389/fonc.2022.925278

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bladder cancer (BC) is one of the world's most frequent cancers. Surgery coupled with adjuvant platinum-based chemotherapy is the current standard of therapy for BC. However, a high proportion of patients progressed to chemotherapy-resistant or even neoplasm recurrence. Hence, identifying novel treatment targets is critical for clinical treatment. Current studies indicated that the Hippo-YAP pathway plays a crucial in regulating the survival of cancer stem cells (CSCs), which is related to the progression and reoccurrence of a variety of cancers. In this review, we summarize the evidence that Hippo-YAP mediates the occurrence, progression and chemotherapy resistance in BC, as well as the role of the Hippo-YAP pathway in regulating bladder cancer stem-like cells (BCSCs). Finally, the clinical potential of Hippo-YAP in the treatment of BC was prospected.

引用

页数：15

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