Surveillance of antibiotic resistance in clinical isolates of streptococcus pneumoniae collected in Belgium during winter 2000-2001

被引:0
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作者
Vanhoof, R
Carpentier, M
Cartuyvels, R
Damée, S
Fagnart, O
Garrino, MG
Glupczynski, Y
Gordts, B
Govaerts, D
Magerman, K
Mans, I
Surmont, I
Van Bossuyt, E
Van De Vyvere, M
Van Landuyt, H
Van Nimmen, L
Van Noyen, R
机构
[1] Pasteurinst Brussel, Eenheid Antibiot Onderzoek, B-1180 Brussels, Belgium
[2] Hop Citadelle, Microbiol Lab, B-4000 Liege, Belgium
[3] Clin St Etienne, Lab Van Den Abbeele, B-1210 Brussels, Belgium
[4] Clin Univ Mt Godinne, Microbiol Lab, B-5530 Yvoir, Belgium
[5] ZA St Jan, Microbiol Lab, B-8000 Brugge, Belgium
[6] CHU Andre Vesale, Microbiol Lab, B-6110 Montignies Le Tilleul, Belgium
[7] Virga Jesseziekenhuis, Microbiol Lab, B-3500 Hasselt, Belgium
[8] H Hartziekenhuis, Microbiol Lab, B-8800 Roeselare, Belgium
[9] AZ Stuivenberg, Microbiol Lab, B-2060 Antwerp, Belgium
[10] AZ Jan Palfijn, Microbiol Lab, B-9000 Ghent, Belgium
[11] Imeldaziekenhuis, Microbiol Lab, B-2820 Bonheiden, Belgium
来源
ACTA CLINICA BELGICA | 2003年 / 58卷 / 02期
关键词
S; pneumoniae; resistance; surveillance;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A total of 314 isolates of Streptococcus pneumoniae collected by 10 different laboratories were tested for their susceptibility by using a microdilution technique following NCCLS recommendations. The following antibiotics were included: penicillin, ampicillin, amoxicillin, amoxicillin/clavulanate, cefaclor, cefuroxime, cefotaxime, imipenem, ciprofloxacin, gemifloxacin, levofloxacin, erythromycin, clarithromycin, azithromycin, miocamycin, clindamycin and tetracycline. The insusceptibility rate (IR) to penicillin was 21.0% [10.8% intermediate (greater than or equal to0.12-1 mug/mL) and 10.2 % high-level (greater than or equal to2 mug/mL)], to cefotaxime 7.3 % [3.5 % intermediate (greater than or equal to 1 mug/mL) and 3.8 % high-level (greater than or equal to2 mug/mL)], to imipenem 3.8 % [3.8 % intermediate (greater than or equal to0.25-0.5 mug/mL) and 0 % high-level (greater than or equal to1 mug/mL)], to ciprofloxacin 11.2 % [8.3 % intermediate (2 mug/mL) and 3.9 % high-level (greater than or equal to4 mug/mL)], to erythromycin 30.3 % [3.5 % intermediate (0.5 mug/mL) and 26.8 % high-level (greater than or equal to1 mug/mL)] and to tetracycline 38.5 % [0.9 % intermediate (4 mug/mL) and 37.6 % high-level (greater than or equal to8 mug/mL)]. No decreased susceptibility was found for gemifloxacin (greater than or equal to0.5 mug/mL). This compound was the most active with MIC50, MIC90 and an IR of 0.015 mug/mL, 0.03 mug/mL, and 0 % respectively, followed by amoxicillin/ clavulanate, amoxicillin and imipenem (MIC50, MIC90 and IR: 0.015 mug/mL, 1 mug/mL, 1.6 %/ 0.015 mug/mL, 1 mug/mL, 1.9 %/ 0.008 mug/mL, 0.12 mug/mL, 3.8 % respectively). Compared to the 1999 surveillance, penicillin and tetracycline-insusceptibility increased with 4.9 % and 15.6% respectively, while cefotaxime, erythromycin and ciprofloxacin insusceptibility decreased with 5.4 %, 5.8 % and 4.4 % respectively. MICs of all beta-lactams rose with those of penicillin for penicillin-insusceptible isolates. Imipenem, cefotaxime, amoxicillin and amoxicillin/clavulanate were generally 4, 2, 1 and 1 doubling dilutions respectively more potent than penicillin on these isolates while ampicillin, cefuroxime and cefaclor were generally 1, 2 and 4 dilutions respectively less potent. Most penicillin-insusceptible isolates remained fully susceptible to amoxicillin/clavulanate (92.4 %), amoxicillin (90.9 %) and imipenem (81.8 %). Erythromycin-tetracycline insusceptibility was the most common resistance phenotype (14.3 %). Three- and four-fold resistance was found in 12.4 % and 1.6 % respectively of the isolates. Most penicillin-insusceptible isolates were of capsular types 14 (22.7 %), 23 (21.2 %), 6 (18.2 %), 9 (13.6 %) and 19 (12.1 %).
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页码:111 / 119
页数:9
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