Segmentation of fiber tracts based on an accuracy analysis on diffusion tensor software phantoms

Due to its unique sensitivity to tissue microstructure, one of the primary applications of diffusion-weighted magnetic resonance imaging is the reconstruction of neural fiber pathways by means of fiber-tracking algorithms. In this work, we make use of realistic diffusion-tensor software phantoms in order to carry out an analysis of the precision of streamline tractography by systematically varying certain properties of the simulated image data (noise, tensor anisotropy, and image resolution) as well as certain fiber-tracking parameters (number of seed points and step length). Building upon the gained knowledge about the precision of the analyzed fiber-tracking algorithm, we proceed by suggesting a fuzzy segmentation algorithm for diffusion tensor images which better estimates the precise spatial extent of a tracked fiber bundle. The presented segmentation algorithm utilizes information given by the estimated main diffusion direction in a voxel and the respective uncertainty, and its validity is confirmed by both qualitative and quantitative analyses. (C) 2011 Elsevier Inc. All rights reserved.