Prenatal exposure to active maternal tobacco smoking elevates risk of cognitive and auditory processing deficits, and of smoking in offspring. Recent preclinical work has demonstrated a sex-specific pattern of reduction in cortical cholinergic markers following prenatal, adolescent, or combined prenatal and adolescent exposure to nicotine, the primary psychoactive component of tobacco smoke. Given the importance of cortical cholinergic neurotransmission to attentional function, we examined auditory and visual selective and divided attention in 181 male and female adolescent smokers and nonsmokers with and without prenatal exposure to maternal smoking. Groups did not differ in age, educational attainment, symptoms of inattention, or years of parent education. A subset of 63 subjects also underwent functional magnetic resonance imaging while performing an auditory and visual selective and divided attention task. Among females, exposure to tobacco smoke during prenatal or adolescent development was associated with reductions in auditory and visual attention performance accuracy that were greatest in female smokers with prenatal exposure (combined exposure). Among males, combined exposure was associated with marked deficits in auditory attention, suggesting greater vulnerability of neurocircuitry supporting auditory attention to insult stemming from developmental exposure to tobacco smoke in males. Activation of brain regions that support auditory attention was greater in adolescents with prenatal or adolescent exposure to tobacco smoke relative to adolescents with neither prenatal nor adolescent exposure to tobacco smoke. These findings extend earlier preclinical work and suggest that, in humans, prenatal and adolescent exposure to nicotine exerts gender-specific deleterious effects on auditory and visual attention, with concomitant alterations in the efficiency of neurocircuitry supporting auditory attention.
机构:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Inst Study Child Dev, New Brunswick, NJ 08903 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Inst Study Child Dev, New Brunswick, NJ 08903 USA
Carmody, Dennis P.
Bennett, David S.
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Drexel Univ, Coll Med, Philadelphia, PA 19144 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Inst Study Child Dev, New Brunswick, NJ 08903 USA
Bennett, David S.
Lewis, Michael
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Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Inst Study Child Dev, New Brunswick, NJ 08903 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Inst Study Child Dev, New Brunswick, NJ 08903 USA
机构:
Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USAUniv So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA
Breton, Carrie V.
Byun, Hyang-Min
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Univ So Calif, Keck Sch Med, Dept Hematol, Los Angeles, CA 90033 USAUniv So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA
Byun, Hyang-Min
Wenten, Made
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Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USAUniv So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA
Wenten, Made
Pan, Fei
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Univ So Calif, Keck Sch Med, Epigenome Canc Ctr, Los Angeles, CA 90033 USAUniv So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA
Pan, Fei
Yang, Allen
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Univ So Calif, Keck Sch Med, Dept Hematol, Los Angeles, CA 90033 USA
Univ So Calif, Keck Sch Med, Epigenome Canc Ctr, Los Angeles, CA 90033 USAUniv So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA
Yang, Allen
Gilliland, Frank D.
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Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USAUniv So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA
机构:
NYU, Sch Med, New York, NY 10027 USANYU, Sch Med, New York, NY 10027 USA
Zhou, Sherry
Rosenthal, David G.
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Univ Washington, Dept Internal Med, Seattle, WA 98195 USANYU, Sch Med, New York, NY 10027 USA
Rosenthal, David G.
Sherman, Scott
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NYU, Sch Med, Dept Populat Hlth & Med, New York, NY USANYU, Sch Med, New York, NY 10027 USA
Sherman, Scott
Zelikoff, Judith
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NYU, Sch Med, New York, NY 10027 USA
NYU, Sch Med, Dept Populat Hlth & Med, New York, NY USANYU, Sch Med, New York, NY 10027 USA
Zelikoff, Judith
Gordon, Terry
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NYU, Sch Med, New York, NY 10027 USA
NYU, Sch Med, Dept Environm Med, New York, NY USANYU, Sch Med, New York, NY 10027 USA
Gordon, Terry
Weitzman, Michael
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NYU, Sch Med, New York, NY 10027 USA
NYU, Sch Med, Dept Environm Med, New York, NY USA
NYU, Sch Med, Dept Pediat, New York, NY USANYU, Sch Med, New York, NY 10027 USA