The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies

被引：93

作者：

Mitsiades, Constantine S. ^{[1
]}

McMillin, Douglas W. ^{[1
]}

Klippel, Steffen ^{[1
]}

Hideshima, Teru ^{[1
]}

Chauhan, Dharminder ^{[1
]}

Richardson, Paul G. ^{[1
]}

Munshi, Nilchil C. ^{[1
]}

Anderson, Kenneth C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Myeloma Ctr,Dept Med Oncol, Boston, MA 02115 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2007年 / 21卷 / 06期

关键词：

D O I：

10.1016/j.hoc.2007.08.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple myeloma (MM) is viewed as a prototypic disease state for the study of how neoplastic cells interact with their local bone marrow (BM) microenvironment. This interaction reflects not only the osteotropic clinical behavior of MM and the clinical impact of the lytic bone lesions caused by its tumor cells but also underlines the broadly accepted notion that nonneoplastic cells of the BM can attenuate the activity of cytotoxic chemotherapy and glucocorticoids. This article summarizes the recent progress in characterization, at the molecular and cellular levels, of how the BM milieu interacts with MM cells and modifies their biologic behavior.

引用

页码：1007 / +

页数：30

共 227 条

[1] Structure and function of the type 1 insulin-like growth factor receptor [J].