Poor sleep quality associates with self-reported psychiatric and cardiometabolic symptoms independently of sleep timing patterns in a large sample of rural and urban workers
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作者:
Carvalho, Felipe Gutierrez
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Univ Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Carvalho, Felipe Gutierrez
[1
,2
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Delgado Cunha, Ana Maria
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Univ Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Delgado Cunha, Ana Maria
[1
]
Tonon, Andre Comiran
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Univ Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Tonon, Andre Comiran
[1
,2
]
Pereira, Fernanda dos Santos
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HCPA, UAMP, Ctr Pesquisa Expt, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Pereira, Fernanda dos Santos
[3
]
Matte, Ursula
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HCPA, Expt Res Ctr, Gene Therapy Ctr, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Matte, Ursula
[4
]
Callegari-Jacques, Sidia Maria
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Univ Fed Rio Grande do Sul, Inst Matemat & Estatist, Dept Estatist, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Callegari-Jacques, Sidia Maria
[5
]
Hidalgo, Maria Paz
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Univ Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
Hidalgo, Maria Paz
[1
,2
]
机构:
[1] Univ Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil
[3] HCPA, UAMP, Ctr Pesquisa Expt, Porto Alegre, RS, Brazil
[4] HCPA, Expt Res Ctr, Gene Therapy Ctr, Porto Alegre, RS, Brazil
[5] Univ Fed Rio Grande do Sul, Inst Matemat & Estatist, Dept Estatist, Porto Alegre, RS, Brazil
Poor sleep associates with mental and cardiometabolic pathological outcomes. The participation of sleep timing features in the pathways by which this relationship occurs is not clear. This study aims to evaluate the interrelationship between sleep quality and self-reported psychiatric/cardiometabolic symptoms, considering mediation and moderation effects of sleep timing patterns, and urban versus rural work environment, respectively; and to verify the association between sleep quality and polymorphisms of AANAT, RORA and TIMELESS genes. An epidemiological survey was performed in a rural area in southern Brazil. Eight-hundred and twenty-nine subjects were evaluated for sleep quality using the Pittsburgh Sleep Quality Index, and sleep timing patterns using the Munich Chronotype Questionnaire. Work characteristics and psychiatric/cardiometabolic symptoms were assessed using a structured self-report questionnaire. Three polymorphisms of AANAT, RORA and TIMELESS (rs3760138, rs782931 and rs774045, respectively) were genotyped in blood samples. We found statistically significant associations of poor sleep quality with self-reported psychiatric symptoms (B = 0.382; 95% CI 0.289-0.476; adjusted p-value <.001), and with self-reported cardiometabolic symptoms (B = 0.079; 95% CI 0.013-0.151; adjusted p-value = .048). The genetic analysis showed that RORA GA/AA genotype was associated to poor sleep quality (B = 0.146, 95% CI 0.054-0.239; adjusted p-value = .004). No moderated mediation effects were observed in the conditional analysis. TIMELESS polymorphism was not included in the analysis due to the low frequency of risk genotypes. These results yield new insights regarding the interrelationship between sleep characteristics and psychiatric/cardiometabolic self-reported symptoms, taking into account genes related to the biological clocks and melatonin pathways.
机构:
NYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
New York Presbyterian Brooklyn Methodist Hosp, Div Pulm & Crit Care Med, Ctr Sleep Disorders, Dept Med, 501 Sixth St, Brooklyn, NY 11215 USANYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
Dubrovsky, B.
Janal, M. N.
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NYU Coll Dent, Dept Epidemiol & Hlth Promot, New York, NY USANYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
Janal, M. N.
Lavigne, G. J.
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Univ Montreal, Fac Med Dent, Montreal, PQ, CanadaNYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
Lavigne, G. J.
Sirois, D. A.
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NYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USANYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
Sirois, D. A.
Wigren, P. E.
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NYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USANYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
Wigren, P. E.
Nemelivsky, L.
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Icahn Sch Med Mt Sinai, Canc Clin Trials Off, New York, NY 10029 USANYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
Nemelivsky, L.
Krieger, A. C.
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机构:
Cornell Univ, Weill Cornell Med Coll, Dept Med, New York, NY 10021 USA
Cornell Univ, Weill Cornell Med Coll, Dept Neurol, New York, NY 10021 USA
Cornell Univ, Weill Cornell Med Coll, Dept Med Genet, New York, NY 10021 USANYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
Krieger, A. C.
Raphael, K. G.
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NYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USANYU Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA
机构:
Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R ChinaSun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Liu, Ru-Qing
Bloom, Michael S.
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Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
SUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, Rensselaer, NY USASun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Bloom, Michael S.
Wu, Qi-Zhen
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Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R ChinaSun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Wu, Qi-Zhen
He, Zhi-Zhou
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Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R ChinaSun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
He, Zhi-Zhou
Qian, Zhengmin
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机构:
St Louis Univ, Dept Epidemiol, Coll Publ Hlth & Social Justice, St Louis, MO 63103 USASun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Qian, Zhengmin
Stamatakis, Katherine A.
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St Louis Univ, Dept Epidemiol, Coll Publ Hlth & Social Justice, St Louis, MO 63103 USASun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Stamatakis, Katherine A.
Liu, Echu
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St Louis Univ, Dept Hlth Management & Policy, Coll Publ Hlth & Social Justice, St Louis, MO 63103 USASun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Liu, Echu
Vaughn, Michael
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St Louis Univ, Sch Social Work, Coll Publ Hlth & Social Justice, St Louis, MO 63103 USASun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Vaughn, Michael
Lawrence, Wayne R.
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SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, Rensselaer, NY USASun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Lawrence, Wayne R.
Yang, Mingan
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San Diego State Univ, Grad Sch Publ Hlth, Dept Biostat & Epidemiol, San Diego, CA 92182 USASun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Yang, Mingan
Lu, Tao
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h-index: 0
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Univ Nevada, Dept Math & Stat, Reno, NV 89557 USASun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Lu, Tao
Hu, Qian-Sheng
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Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R ChinaSun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
Hu, Qian-Sheng
Dong, Guang-Hui
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Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R ChinaSun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Sch Publ Hlth, Dept Prevent Med, Guangzhou, Guangdong, Peoples R China
机构:
Sichuan Univ, Inst Emergency Management & Postdisaster Reconstr, Chengdu, Sichuan, Peoples R China
Sichuan Univ, Ctr Educ & Hlth Psychol, Chengdu, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, Inst Emergency Management & Postdisaster Reconstr, Chengdu, Sichuan, Peoples R China
Tang, Wanjie
Lu, Yi
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Sichuan Univ, Inst Emergency Management & Postdisaster Reconstr, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, Inst Emergency Management & Postdisaster Reconstr, Chengdu, Sichuan, Peoples R China
Lu, Yi
Yang, Yanchun
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Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, Inst Emergency Management & Postdisaster Reconstr, Chengdu, Sichuan, Peoples R China
Yang, Yanchun
Xu, Jiuping
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Sichuan Univ, Inst Emergency Management & Postdisaster Reconstr, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, Inst Emergency Management & Postdisaster Reconstr, Chengdu, Sichuan, Peoples R China
机构:
Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, IranUniv Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, Iran
Yazdani, Vida
Zeraattalab-Motlagh, Sheida
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Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, IranUniv Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, Iran
Zeraattalab-Motlagh, Sheida
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Jayedi, Ahmad
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Majdi, Maryam
Mirrafiei, Amin
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Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, IranUniv Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, Iran
Mirrafiei, Amin
Martami, Fahimeh
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Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, IranUniv Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, Iran
Martami, Fahimeh
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Djafarian, Kurosh
Shab-Bidar, Sakineh
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Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, IranUniv Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, Iran