Poor sleep quality associates with self-reported psychiatric and cardiometabolic symptoms independently of sleep timing patterns in a large sample of rural and urban workers

被引:2
|
作者
Carvalho, Felipe Gutierrez [1 ,2 ]
Delgado Cunha, Ana Maria [1 ]
Tonon, Andre Comiran [1 ,2 ]
Pereira, Fernanda dos Santos [3 ]
Matte, Ursula [4 ]
Callegari-Jacques, Sidia Maria [5 ]
Hidalgo, Maria Paz [1 ,2 ]
机构
[1] Univ Fed Rio Grande do Sul, HCPA, Lab Cronobiol & Sono, 2350 Ramiro Barcelos St, BR-90035903 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil
[3] HCPA, UAMP, Ctr Pesquisa Expt, Porto Alegre, RS, Brazil
[4] HCPA, Expt Res Ctr, Gene Therapy Ctr, Porto Alegre, RS, Brazil
[5] Univ Fed Rio Grande do Sul, Inst Matemat & Estatist, Dept Estatist, Porto Alegre, RS, Brazil
关键词
biological rhythms; chronobiology; circadian rhythm; genetics; N-ACETYLTRANSFERASE; CIRCADIAN-RHYTHMS; GENETICS; EXPRESSION; GENES;
D O I
10.1111/jsr.12969
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Poor sleep associates with mental and cardiometabolic pathological outcomes. The participation of sleep timing features in the pathways by which this relationship occurs is not clear. This study aims to evaluate the interrelationship between sleep quality and self-reported psychiatric/cardiometabolic symptoms, considering mediation and moderation effects of sleep timing patterns, and urban versus rural work environment, respectively; and to verify the association between sleep quality and polymorphisms of AANAT, RORA and TIMELESS genes. An epidemiological survey was performed in a rural area in southern Brazil. Eight-hundred and twenty-nine subjects were evaluated for sleep quality using the Pittsburgh Sleep Quality Index, and sleep timing patterns using the Munich Chronotype Questionnaire. Work characteristics and psychiatric/cardiometabolic symptoms were assessed using a structured self-report questionnaire. Three polymorphisms of AANAT, RORA and TIMELESS (rs3760138, rs782931 and rs774045, respectively) were genotyped in blood samples. We found statistically significant associations of poor sleep quality with self-reported psychiatric symptoms (B = 0.382; 95% CI 0.289-0.476; adjusted p-value <.001), and with self-reported cardiometabolic symptoms (B = 0.079; 95% CI 0.013-0.151; adjusted p-value = .048). The genetic analysis showed that RORA GA/AA genotype was associated to poor sleep quality (B = 0.146, 95% CI 0.054-0.239; adjusted p-value = .004). No moderated mediation effects were observed in the conditional analysis. TIMELESS polymorphism was not included in the analysis due to the low frequency of risk genotypes. These results yield new insights regarding the interrelationship between sleep characteristics and psychiatric/cardiometabolic self-reported symptoms, taking into account genes related to the biological clocks and melatonin pathways.
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页数:10
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