Accelerated ageing and degradation in poly-L-lactide/hydroxyapatite nanocomposites

被引：37

作者：

Delabarde, Claire ^{[1
]}

Plummer, Christopher J. G. ^{[1
]}

Bourban, Pierre-Etienne ^{[1
]}

Manson, Jan-Anders E. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Technol Composites & Polymeres LTC, CH-1015 Lausanne, Switzerland

来源：

POLYMER DEGRADATION AND STABILITY | 2011年 / 96卷 / 04期

关键词：

Ageing; Degradation; PLLA; Hydroxyapatite; Nanocomposite; Mechanical properties; SYNTHETIC BIODEGRADABLE POLYMERS; IN-VIVO DEGRADATION; POLY(L-LACTIC ACID); HYDROLYTIC DEGRADATION; MECHANICAL-PROPERTIES; POLY(LACTIC ACID); PHYSIOLOGICAL TEMPERATURE; BIORESORBABLE COMPOSITES; TRICALCIUM PHOSPHATE; ALKALINE-SOLUTION;

D O I：

10.1016/j.polymdegradstab.2010.12.018

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Dry, compression molded films of medical grade poly-L-lactide (PLLA) showed a marked reduction in tensile strength and strain after accelerated ageing in aqueous NaOH at 50 degrees C. accompanied by mass loss, surface erosion, increased hydrophilicity and, in the case of the initially amorphous films, cold crystallization owing to the plasticizing effect of the ageing medium. Addition of well dispersed nanosized hydroxyapatite (nHA) particles resulted in increases in the rate of mass loss during ageing, identified with accelerated degradation at the matrix/particle interfaces. However, the associated decreases in tensile strength and strain to fail with ageing time were far less marked in the presence of the nHA than in the unmodified films. This implied that nHA acts as an effective toughener of the bulk material, consistent with TEM observations of the deformed films, which indicated failure of the particle-matrix interfaces to promote plastic deformation of the PLLA. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：595 / 607

页数：13

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