Angiogenesis induction in breast cancer: A paracrine paradigm

被引：41

作者：

Badodekar, Nilaja ^{[1
]}

Sharma, Akshita ^{[2
]}

Patil, Vikrant ^{[1
]}

Telang, Gaurang ^{[1
]}

Sharma, Rakesh ^{[3
]}

Patil, Shankargouda ^{[4
]}

Vyas, Nishant ^{[1
]}

Somasundaram, Indumathi ^{[2
]}

机构：

[1] Log Life Sci Pvt Ltd, Pune, Maharashtra, India

[2] DY Patil Educ Soc, Dept Stem Cell & Regenerat Med, Kolhapur, Maharashtra, India

[3] DY Patil Med Coll, Dept Obstet & Gynaecol, Kolhapur, Maharashtra, India

[4] Jazan Univ, Coll Dent, Dept Maxilofacial Surg & Diagnost Sci, Div Oral Pathol, Jazan, Saudi Arabia

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2021年 / 39卷 / 07期

关键词：

angiogenesis; breast cancer; hypoxia-inducing factor; mast cell; vasculogenesis; ENDOTHELIAL GROWTH-FACTOR; TUMOR-ASSOCIATED MACROPHAGES; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; MATRIX METALLOPROTEINASES; PHASE-II; MAST-CELLS; FACTOR-B; MOLECULAR-MECHANISMS; VASCULAR DENSITY; FACTOR RECEPTOR;

D O I：

10.1002/cbf.3663

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is the most prevalent type of cancer among women globally. Angiogenesis contributes significantly to breast cancer progression and dissemination. Neovascularization is concurrent with the progression and growth of breast cancer. Breast cancer cells control angiogenesis by secreting pro-angiogenic factors like fibroblast growth factor, vascular endothelial growth factor, interleukin, transforming growth factor-beta, platelet-derived growth factor and several others. These pro-angiogenic factors trigger neovascularization, and thereby lead to breast cancer development and metastasis. The hypoxia-inducible factor (HIF)-regulated angiogenesis cascade is a crucial underlying factor in breast cancer growth and metastasis. To that end, several efforts have been made to identify druggable targets within the HIF-angiogenesis components. However, escape pathways are a major hindrance for targeted therapies against angiogenesis. Thus, understanding the key factors that trigger breast cancer angiogenesis is critical in elucidating ways to inhibit breast cancer. The current review provides an overview of the key growth factors that trigger breast cancer angiogenesis.

引用

页码：860 / 873

页数：14

共 128 条

[1] The fibroblast growth factor-binding protein FGF-BP [J].