Silatrane-sulfonamide hybrids: Synthesis, characterization, and evaluation of biological activity

A series of novel sulfonamide-bridged silatranes 3,4,6,7 has been synthesized by the reaction of N,N-dichloroarylsulfonamides la-d with 1-vinylsilatrane 2 and 1-allylsilatrane 5. The structure of the silatrane-sulfonamide hybrids is characterized by elemental analysis, FT-IR, NMR (H-1, C-13, Si-29 and N-15) spectroscopy, high-resolution mass spectrometry, and X-ray diffraction analysis. The resulting hybrids 4ad and 7a-d have been investigated by computational screening via ADMET and PASS. These compounds exhibit drug-like features, bioavailability and may have high enzyme-inhibitory activity. The screening (in vitro) of hybrids 4a,b,d and 7a,b for antimicrobial activities against pathogenic bacterial strains shows that these compounds possess antibacterial properties. (C) 2021 Elsevier B.V. All rights reserved.