A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

被引：108

作者：

Raffan, Eleanor ^{[1
]}

Dennis, Rowena J. ^{[1
]}

O'Donovan, Conor J. ^{[1
]}

Becker, Julia M. ^{[1
]}

Scott, Robert A. ^{[2
]}

Smith, Stephen P. ^{[3
]}

Withers, David J. ^{[1
]}

Wood, Claire J. ^{[1
]}

Conci, Elena ^{[1
]}

Clements, Dylan N. ^{[4
,5
]}

Summers, Kim M. ^{[4
]}

German, Alexander J. ^{[6
]}

Mellersh, Cathryn S. ^{[7
]}

Arendt, Maja L. ^{[8
]}

Iyemere, Valentine P. ^{[1
]}

Withers, Elaine ^{[1
]}

Soder, Josefin ^{[9
]}

Wernersson, Sara ^{[9
]}

Andersson, Goran ^{[10
]}

Lindblad-Toh, Kerstin ^{[11
,12
]}

Yeo, Giles S. H. ^{[1
]}

O'Rahilly, Stephen ^{[1
]}

机构：

[1] Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England

[2] Univ Cambridge, WT MRC Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

[3] Univ Cambridge, Sch Clin Med, Cambridge CB2 0SP, England

[4] Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland

[5] Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush EH25 9RG, Midlothian, Scotland

[6] Univ Liverpool, Inst Ageing & Chron Dis, Neston CH64 7TE, Cheshire, England

[7] Anim Hlth Trust, Dept Canine Genet, Newmarket CB8 7UU, Suffolk, England

[8] Uppsala Univ, IMBIM, S-75123 Uppsala, Sweden

[9] Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, S-75007 Uppsala, Sweden

[10] Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden

[11] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

[12] Sci Life Lab, S-75123 Uppsala, Sweden

来源：

CELL METABOLISM | 2016年 / 23卷 / 05期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

OWNER-PERCEIVED OBESITY; RISK-FACTORS; VETERINARY PRACTICES; BETA-ENDORPHIN; DIET;

D O I：

10.1016/j.cmet.2016.04.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the b-MSH and beta-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

引用

页码：893 / 900

页数：8

共 33 条

[1]

[Anonymous], 2016, Stata Statistical Software: Release 12

[2] A role for the endogenous opioid β-endorphin in energy homeostasis [J].

Appleyard, SM ;

Hayward, M ;

Young, JI ;

Butler, AA ;

Cone, RD ;

Rubinstein, M ;

Low, MJ .

ENDOCRINOLOGY, 2003, 144 (05) :1753-1760

[3] A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism [J].

Challis, BG ;

Pritchard, LE ;

Creemers, JWM ;

Delplanque, J ;

Keogh, JM ;

Luan, J ;

Wareham, NJ ;

Yeo, GSH ;

Bhattacharyya, S ;

Froguel, P ;

White, A ;

Farooqi, IS ;

O'Rahilly, S .

HUMAN MOLECULAR GENETICS, 2002, 11 (17) :1997-2004

[4] Risk factors for obesity in dogs in France [J].

Colliard, L ;

Ancel, J ;

Benet, JJ ;

Paragon, BM ;

Blanchard, G .

JOURNAL OF NUTRITION, 2006, 136 (07) :1951S-1954S

[5] An epidemiological study of environmental factors associated with canine obesity [J].

Courcier, E. A. ;

Thomson, R. M. ;

Mellor, D. J. ;

Yam, P. S. .

JOURNAL OF SMALL ANIMAL PRACTICE, 2010, 51 (07) :362-367

[6]

Day J. E. L., 2009, CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, V4, P1, DOI 10.1079/PAVSNNR20094042

[7] STUDY OF OBESITY IN DOGS VISITING VETERINARY PRACTICES IN THE UNITED-KINGDOM [J].

EDNEY, ATB ;

SMITH, PM .

VETERINARY RECORD, 1986, 118 (14) :391-396

[8]

German AJ, 2006, J NUTR, V136, p1940S, DOI 10.1093/jn/136.7.1940S

[9]

Laflamme D, 1997, CANINE PRACT, V22, P10

[10] Diet restriction and ageing in the dog: major observations over two decades [J].

Lawler, Dennis F. ;

Larson, Brian T. ;

Ballam, Joan M. ;

Smith, Gail K. ;

Biery, Darryl N. ;

Evans, Richard H. ;

Greeley, Elizabeth H. ;

Segre, Mariangela ;

Stowe, Howard D. ;

Kealy, Richard D. .

BRITISH JOURNAL OF NUTRITION, 2008, 99 (04) :793-805

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