HSPA1A is upregulated in periodontal ligament at early stage of tooth movement in rats

被引：29

作者：

Arai, Chihiro ^{[1
]}

Nomura, Yoshiaki ^{[2
]}

Ishikawa, Misao ^{[1
]}

Noda, Koji ^{[1
]}

Choi, Jae-Won ^{[1
]}

Yashiro, Yuichi ^{[1
]}

Hanada, Nobuhiro ^{[2
]}

Nakamura, Yoshiki ^{[1
]}

机构：

[1] Tsurumi Univ, Sch Dent Med, Dept Orthodont, Tsurumi Ku, Kanagawa 2308501, Japan

[2] Tsurumi Univ, Sch Dent Med, Dept Translat Res, Tsurumi Ku, Kanagawa 2308501, Japan

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2010年 / 134卷 / 04期

关键词：

HSPA1A; LMD; Gene expression; Periodontal ligament; Orthodontic tooth movement; HEAT-SHOCK PROTEINS; DEGENERATING TISSUES; APAF-1; APOPTOSOME; MECHANICAL-STRESS; HSP70; CELLS; HEAT-SHOCK-PROTEIN-70; INCIDENT; PATHWAY;

D O I：

10.1007/s00418-010-0737-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heat shock proteins (HSPs) are molecular chaperones that maintain intracellular protein homeostasis and ensure survival of cells. Continuous orthodontic force on the tooth is considered to be a type of physical stress loaded to the periodontal ligament (PDL). However, little is known about the role of HSPs during tooth movement. This study was performed to examine the expression of HSPs in the PDL during tooth movement using laser microdissection, microarray analysis, real-time RT-PCR and immunohistochemistry. Gene expression of HSPA1A in the pressure zone of the PDL was higher during 6 h of tooth movement than in the control group. Expression of HSPA1A decreased with time. HSPA1A was also detected in the pressure zone of the PDL at the protein level 24 h after the initial tissue change. These results strongly suggest that expression of HSPA1A in the PDL during early stages of tooth movement is a critical factor for tissue reaction.

引用

页码：337 / 343

页数：7

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