HSPA1A is upregulated in periodontal ligament at early stage of tooth movement in rats

被引：29

作者：

Arai, Chihiro ^{[1
]}

Nomura, Yoshiaki ^{[2
]}

Ishikawa, Misao ^{[1
]}

Noda, Koji ^{[1
]}

Choi, Jae-Won ^{[1
]}

Yashiro, Yuichi ^{[1
]}

Hanada, Nobuhiro ^{[2
]}

Nakamura, Yoshiki ^{[1
]}

机构：

[1] Tsurumi Univ, Sch Dent Med, Dept Orthodont, Tsurumi Ku, Kanagawa 2308501, Japan

[2] Tsurumi Univ, Sch Dent Med, Dept Translat Res, Tsurumi Ku, Kanagawa 2308501, Japan

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2010年 / 134卷 / 04期

关键词：

HSPA1A; LMD; Gene expression; Periodontal ligament; Orthodontic tooth movement; HEAT-SHOCK PROTEINS; DEGENERATING TISSUES; APAF-1; APOPTOSOME; MECHANICAL-STRESS; HSP70; CELLS; HEAT-SHOCK-PROTEIN-70; INCIDENT; PATHWAY;

D O I：

10.1007/s00418-010-0737-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heat shock proteins (HSPs) are molecular chaperones that maintain intracellular protein homeostasis and ensure survival of cells. Continuous orthodontic force on the tooth is considered to be a type of physical stress loaded to the periodontal ligament (PDL). However, little is known about the role of HSPs during tooth movement. This study was performed to examine the expression of HSPs in the PDL during tooth movement using laser microdissection, microarray analysis, real-time RT-PCR and immunohistochemistry. Gene expression of HSPA1A in the pressure zone of the PDL was higher during 6 h of tooth movement than in the control group. Expression of HSPA1A decreased with time. HSPA1A was also detected in the pressure zone of the PDL at the protein level 24 h after the initial tissue change. These results strongly suggest that expression of HSPA1A in the PDL during early stages of tooth movement is a critical factor for tissue reaction.

引用

页码：337 / 343

页数：7

共 50 条

[21] Periodontal response to orthodontic tooth movement in diabetes-induced rats with or without periodontal disease [J].

Ferreira, Camila Lopes ;

da Rocha, Vinicius Clemente ;

da Silva Ursi, Weber Jose ;

De Marco, Andrea Carvalho ;

Santamaria, Milton ;

Santamaria, Mauro Pedrine ;

Neves Jardini, Maria Aparecida .

JOURNAL OF PERIODONTOLOGY, 2018, 89 (03) :341-350

[22] Localization of glycosaminoglycans in periodontal ligament during physiological and experimental tooth movement [J].

Kagayama, M ;

Sasano, Y ;

Mizoguchi, I ;

Kamo, N ;

Takahashi, I ;

Mitani, H .

JOURNAL OF PERIODONTAL RESEARCH, 1996, 31 (04) :229-234

[23] Immunolocalization of lubricin in the rat periodontal ligament during experimental tooth movement [J].

Leonardi, Rosalia ;

Loreto, Carla ;

Talic, Nabeel ;

Caltabiano, Rosario ;

Musumeci, Giuseppe .

ACTA HISTOCHEMICA, 2012, 114 (07) :700-704

[24] Rapid tooth movement through distraction osteogenesis of the periodontal ligament in dogs [J].

AI Hong ;

Xu Qing-Feng ;

Lu Hong-Fei ;

Mai Zhi-Hui ;

An Ai-Qun ;

Liu Guo-Ping .

CHINESE MEDICAL JOURNAL, 2008, 121 (05) :455-462

[25] Vesicular nucleotide transporter mediates adenosine triphosphate release in compressed human periodontal ligament fibroblast cells and participates in tooth movement-induced nociception in rats [J].

Mizuhara, Masahiro ;

Kometani-Gunjigake, Kaori ;

Nakao-Kuroishi, Kayoko ;

Toyono, Takashi ;

Hitomi, Suzuro ;

Morii, Aoi ;

Shiga, Momotoshi ;

Seta, Yuji ;

Ono, Kentaro ;

Kawamoto, Tatsuo .

ARCHIVES OF ORAL BIOLOGY, 2020, 110

[26] Obesity affects the proteome profile of periodontal ligament submitted to mechanical forces induced by orthodontic tooth movement in rats [J].

Marcantonio, Camila Chierici ;

Lopes, Maria Eduarda Scordamaia ;

Mofatto, Luciana Souto ;

Salmon, Cristiane Ribeiro ;

Deschner, James ;

Nociti-Junior, Francisco Humberto ;

Cirelli, Joni Augusto ;

Nogueira, Andressa Vilas Boas .

JOURNAL OF PROTEOMICS, 2022, 263

[27] Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats [J].

Takahashi, I ;

Nishimura, M ;

Onodera, K ;

Bae, JW ;

Mitani, H ;

Okazaki, M ;

Sasano, Y ;

Mitani, H .

JOURNAL OF DENTAL RESEARCH, 2003, 82 (08) :646-651

[28] Delayed recruitment of immunocompetent cells in denervated rat periodontal ligament following experimental tooth movement [J].

Vandevska-Radunovic, V ;

Kvinnsland, S ;

Jonsson, R .

JOURNAL OF DENTAL RESEARCH, 1999, 78 (06) :1214-1220

[29] An immunofluorescence study on VEGF and extracellular matrix proteins in human periodontal ligament during tooth movement [J].

Militi, Angela ;

Cutroneo, Giuseppina ;

Favaloro, Angelo ;

Matarese, Giovanni ;

Di Mauro, Debora ;

Lauritano, Floriana ;

Centofanti, Antonio ;

Cervino, Gabriele ;

Nicita, Fabiana ;

Bramanti, Alessia ;

Rizzo, Giuseppina .

HELIYON, 2019, 5 (10)

[30] Genetic polymorphisms influence gene expression of human periodontal ligament fibroblasts in the early phases of orthodontic tooth movement [J].

Erika Calvano Küchler ;

Agnes Schröder ;

Paola Corso ;

Rafaela Scariot ;

Gerrit Spanier ;

Peter Proff ;

Christian Kirschneck .

Odontology, 2020, 108 :493-502

← 1 2 3 4 5 →