Combining Repetitive Transcranial Magnetic Stimulation and Video Game-Based Training to Improve Dexterity in Parkinson's Disease: Study Protocol of a Randomized Controlled Trial

被引:0
作者
Pastore-Wapp, Manuela [1 ,2 ]
Lehnick, Dirk [3 ,4 ]
Nef, Tobias [2 ]
Bohlhalter, Stephan [1 ,5 ]
Vanbellingen, Tim [1 ,2 ]
机构
[1] Luzerner Kantonsspital, Neuroctr, Luzern, Switzerland
[2] Univ Bern, ARTORG Ctr Biomed Engn Res, Gerontechnol & Rehabil Grp, Bern, Switzerland
[3] Clin Trials Unit Cent Switzerland, Biostat & Methodol, Luzern, Switzerland
[4] Univ Lucerne, Dept Hlth Sci & Med, Luzern, Switzerland
[5] Univ Zurich, Zurich, Switzerland
来源
FRONTIERS IN REHABILITATION SCIENCES | 2021年 / 2卷
关键词
Parkinson's disease; transcranial magnetic stimulation; dexterity; video game-based training; RCT; randomized controlled trial; THETA-BURST-STIMULATION; MONTREAL COGNITIVE ASSESSMENT; SUPPLEMENTARY MOTOR AREA; SCREENING TOOL; EXCITABILITY; RTMS; ACCURACY; AKINESIA; RECOVERY;
D O I
10.3389/fresc.2021.777981
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Introduction: Patients with Parkinson's disease (PD) often exhibit difficulties with dexterity during the performance of activities of daily living (ADL) due to dysfunctional supplementary motor area (SMA). The aim of this clinical trial protocol work is to describe how the effectiveness of a combined repetitive transcranial magnetic stimulation (rTMS) over SMA and video-game-based skill training (VBT) in PD will be evaluated. The short and long-term benefits are assessed.Methods and analysis: A single-blind (patients) stratified (based on Hoehn & Yahr) parallel randomized sham-controlled rTMS-VBT study with a baseline and two follow-up measurements (3 and 12 weeks) is being conducted. These measurements include the dexterity questionnaire 24 (DextQ-24) as a primary outcome, and nine hole peg test and coin rotation task as main secondary dexterity outcomes. Further secondary outcomes will be the subscale II of the movement disorders society unified PD rating scale (MDS-UPDRS) to assess improvements on overall ADL and the Parkinson's Disease Questionnaire-39 to assess quality of life. Thirty-six outpatients (from one neurorehabilitation center) with PD (diagnosis based on brain bank criteria) will be recruited who report difficulties with dexterity in performing ADL. All PD patients will receive a 45-min VBT three times a week for 3 weeks. The PD patients randomized in the experimental group will receive VBT preceded by real rTMS, being intermittent theta burst (iTBS) stimulation sessions. The PD patients randomized to the control group receive a VBT with sham rTMS.Discussion: The study will provide evidence to determine whether a combined iTBS and VBT skill intervention is more effective than a VBT intervention alone to improve dexterity in PD.Ethics and dissemination: The study was approved by the Ethics Committee for Northwest and Central Switzerland (EKNZ), Switzerland 2019-00433. The study will be conducted in accordance with the Helsinki Declaration and the Guidelines of Good Clinical Practice. Informed consent will be signed prior to subject enrolment. Dissemination will include submission to international peer-reviewed professional journals and presentation at international congresses.The study protocol has been registered in the clinicaltrials.gov registry with the identification code: NCT04699149.
引用
收藏
页数:8
相关论文
共 50 条
[41]   Repetitive transcranial magnetic stimulation transiently reduces punding in Parkinson’s disease: a preliminary study [J].
Raffaele Nardone ;
Pierpaolo De Blasi ;
Yvonne Höller ;
Monica Christova ;
Frediano Tezzon ;
Eugen Trinka ;
Francesco Brigo .
Journal of Neural Transmission, 2014, 121 :267-274
[42]   Leap motion controlled video game-based therapy for upper limb rehabilitation in patients with Parkinson's disease: a feasibility study [J].
Fernandez-Gonzalez, Pilar ;
Carratala-Tejada, Maria ;
Monge-Pereira, Esther ;
Collado-Vazquez, Susana ;
Sanchez-Herrera Baeza, Patricia ;
Cuesta-Gomez, Alicia ;
Daniel Ona-Simbana, Edwin ;
Jardon-Huete, Alberto ;
Molina-Rueda, Francisco ;
Balaguer-Bernaldo de Quiros, Carlos ;
Carlos Miangolarra-Page, Juan ;
Cano-de la Cuerda, Roberto .
JOURNAL OF NEUROENGINEERING AND REHABILITATION, 2019, 16 (01)
[43]   Leap motion controlled video game-based therapy for upper limb rehabilitation in patients with Parkinson’s disease: a feasibility study [J].
Pilar Fernández-González ;
María Carratalá-Tejada ;
Esther Monge-Pereira ;
Susana Collado-Vázquez ;
Patricia Sánchez-Herrera Baeza ;
Alicia Cuesta-Gómez ;
Edwin Daniel Oña-Simbaña ;
Alberto Jardón-Huete ;
Francisco Molina-Rueda ;
Carlos Balaguer-Bernaldo de Quirós ;
Juan Carlos Miangolarra-Page ;
Roberto Cano-de la Cuerda .
Journal of NeuroEngineering and Rehabilitation, 16
[44]   Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep in Individuals With Insomnia Symptoms: Protocol for a Double-Blind Randomized Controlled Trial [J].
Hildebrand, Lindsey ;
Huskey, Alisa ;
Dailey, Natalie ;
Jankowski, Samantha ;
Henderson-Arredondo, Kymberly ;
Trapani, Christopher ;
Patel, Salma Imran ;
Chen, Allison Yu -Chin ;
Chou, Ying-Hui ;
Killgore, William D. S. .
JMIR RESEARCH PROTOCOLS, 2024, 13
[45]   Repetitive Transcranial Magnetic Stimulation (rTMS) for the cognitive rehabilitation of traumatic brain injury (TBI) victims: study protocol for a randomized controlled trial [J].
Neville, Iuri Santana ;
Hayashi, Cintya Yukie ;
El Hajj, Simone Alves ;
Costa Zaninotto, Ana Luiza ;
Sabino, Juliana Perez ;
Sousa, Leonardo Moura, Jr. ;
Nagumo, Marcia Mitie ;
Brunoni, Andre Russowsky ;
Silva Shieh, Barbara Dal Forno ;
Oliveira Amorim, Robson Luis ;
Teixeira, Manoel Jacobsen ;
Paiva, Wellingson Silva .
TRIALS, 2015, 16
[46]   Repetitive Transcranial Magnetic Stimulation (rTMS) for the cognitive rehabilitation of traumatic brain injury (TBI) victims: study protocol for a randomized controlled trial [J].
Iuri Santana Neville ;
Cintya Yukie Hayashi ;
Simone Alves El Hajj ;
Ana Luiza Costa Zaninotto ;
Juliana Perez Sabino ;
Leonardo Moura Sousa ;
Marcia Mitie Nagumo ;
André Russowsky Brunoni ;
Barbara Dal Forno Silva Shieh ;
Robson Luis Oliveira Amorim ;
Manoel Jacobsen Teixeira ;
Wellingson Silva Paiva .
Trials, 16
[47]   The effects of combining repetitive transcranial magnetic stimulation with task-specific training on gait performance in individuals with Parkinson's disease: A review article [J].
Niemrungruang, Kanjana ;
Thanakamchokchai, Jenjira ;
Pongmala, Chatkaew ;
Khobkhun, Fuengfa .
PHYSIOTHERAPY RESEARCH INTERNATIONAL, 2024, 29 (03)
[48]   Repetitive transcranial magnetic stimulation for cognitive impairment in Alzheimer's disease: a meta-analysis of randomized controlled trials [J].
Wang, Xin ;
Mao, Zhiqi ;
Ling, Zhipei ;
Yu, Xinguang .
JOURNAL OF NEUROLOGY, 2020, 267 (03) :791-801
[49]   Randomized controlled trial protocol: balance training with rhythmical cues to improve and maintain balance control in Parkinson's disease [J].
da Costa Capato, Tamine Teixeira ;
Tornai, Juliana ;
Avila, Patricia ;
Barbosa, Egberto Reis ;
Pimentel Piemonte, Maria Elisa .
BMC NEUROLOGY, 2015, 15
[50]   Randomized controlled trial protocol: balance training with rhythmical cues to improve and maintain balance control in Parkinson’s disease [J].
Tamine Teixeira da Costa Capato ;
Juliana Tornai ;
Patrícia Ávila ;
Egberto Reis Barbosa ;
Maria Elisa Pimentel Piemonte .
BMC Neurology, 15