Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma

被引：17

作者：

Jovanovic, Lidija ^{[1
]}

Delahunt, Brett ^{[1
]}

McIver, Bryan ^{[3
]}

Eberhardt, Norman L. ^{[3
,4
]}

Bhattacharya, Alokananda ^{[2
]}

Lea, Rod ^{[2
]}

Grebe, Stefan K. G. ^{[3
,5
]}

机构：

[1] Univ Otago, Wellington Sch Med & Hlth Sci, Dept Pathol & Mol Med, Wellington, New Zealand

[2] ESR Kenepuru Sci Ctr, Porirua, New Zealand

[3] Mayo Clin, Dept Med, Rochester, MN USA

[4] Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN USA

[5] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

来源：

PATHOLOGY | 2010年 / 42卷 / 06期

关键词：

Multifocal papillary thyroid carcinoma; phenotypic diversity; allelic imbalances; loss of heterozygosity; BRAF(V600E) mutation; FREQUENT ALLELIC LOSSES; TUMOR-SUPPRESSOR GENES; TALL-CELL VARIANT; FOLLICULAR VARIANT; PROSTATE-CANCER; CLONAL ORIGIN; HETEROZYGOSITY; INSTABILITY; PROGRESSION; LESIONS;

D O I：

10.3109/00313025.2010.508780

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aims: This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC). Methods: Loss of heterozygosity (LOH) and BRAF(V600E) mutation status were analysed in a total of 55 individual tumour foci from 18 cases of mPTC. The genetic findings and morphology of tumour foci were then compared. Results: Multifocal PTC LOH rates were higher than observed previously in solitary PTC. Different patterns of LOH and BRAF(V600E) positivity separated follicular variant tumours and tumour foci from other PTC histological subtypes. In five cases, genetic alterations were detected in morphologically normal thyroid epithelium. Conclusions: These findings support the concept that multifocal PTCs develop through clonal selection from a field of pre-neoplastic cells, with morphotype differentiation correlating with specific tumour-genetic alterations. The relatively high genetic disarray in multifocal PTC may underlie their ability to spread throughout the thyroid gland.

引用

页码：524 / 533

页数：10

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