Caffeate and piperidine-3-ol derivatives from the stem bark of Cassia sieberiana

被引：2

作者：

Atontsa, Brice Cedric K. ^{[1
]}

Bitchagno, Gabin Thierry M. ^{[1
,2
]}

Mpetga, James D. Simo ^{[1
]}

Wamba, Brice Elvis N. ^{[3
]}

Nayim, Paul ^{[3
]}

Tchuenguem, Roland T. ^{[3
]}

Ndontsa, Blanche L. ^{[1
]}

Koagne, Romeol R. ^{[1
]}

Opatz, Till ^{[2
]}

Kuete, Victor ^{[3
]}

Tane, Pierre ^{[1
]}

机构：

[1] Univ Dschang, Dept Chem, Dschang, Cameroon

[2] Johannes Gutenberg Univ Mainz, Inst Organ Chem, Mainz, Germany

[3] Univ Dschang, Dept Biochem, Dschang, Cameroon

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 15期

关键词：

Cassia sieberiana; Fabaceae; caffeate derivative; antioxidant activity; antibacterial activity; CONSTITUENTS; EXTRACTS;

D O I：

10.1080/14786419.2019.1684278

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new caffeate derivative from the ethanol extract of the stem bark of Cassia sieberiana DC. is described herein along with the known secondary metabolites spectaline (2), iso-6-cassine (3), 3-O-methyl-chiro-inositol (4), monobehenin (5), octyl nonadecyloate (6), beta-sitosterol (7), stigmasterol (8) and sitosterol 3-O-beta-D-glucopyranoside (9). The chemical structures were elucidated by means of various spectroscopic and spectrometric techniques. Extract and isolated compounds were devoid of inhibitory action against the herein selected bacterial strains (MICs > 256 mu g/mL) but showed capacities to reduce 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (EC50 < 3 mu g/mL) considerably better than the "gold standard" trolox (EC50 6.47 +/- 0.48 mu g/mL).

引用

页码：2507 / 2514

页数：8

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